PT  - JOURNAL ARTICLE
AU  - Vasu, Srivatsan Thirumalai
AU  - Raheja, Lakshay
AU  - Parmar, Kanishk
AU  - Ramachandran, Sudheesh
TI  - Efficacy and Safety Profile of Tranexamic Acid in Traumatic Thoracolumbar Fracture Management: A Systematic Review and Meta-Analysis
AID  - 10.14444/8257
DP  - 2022 May 19
TA  - International Journal of Spine Surgery
PG  - 8257
4099  - https://www.ijssurgery.com/content/early/2022/05/18/8257.short
4100  - https://www.ijssurgery.com/content/early/2022/05/18/8257.full
AB  - Objective In this article, the authors systematically evaluated the efficacy and safety of tranexamic acid (TXA) in surgeries for spinal trauma.Methods Potentially relevant academic articles were identified from the Cochrane Library, MEDLINE, PubMed, and Google Scholar. Secondary sources were identified from the references of the included literature. RevMan software was used to analyze the pooled data.Results A total of 7 randomized controlled trials (RCTs) and 2 non-RCTs were included in the review. There were significant differences in total blood loss (standard mean difference [SMD] = −2.54 [95% CI, −3.72, −1.37], P = 0.0001), intraoperative blood loss (SMD = −0.96 [95% CI, −1.28, −0.64], P < 0.00001), postoperative blood loss (SMD = −1.42 [95% CI, −1.72, −1.11], P < 0.00001), and length of hospital stay (SMD = −3.73 [95% CI, −4.41, −3.06], P = 0.00001). No significant differences were found regarding transfusion requirement, operative duration, deep vein thrombosis, and pulmonary embolism between the 2 groups.Conclusions The present meta-analysis indicates that the use of TXA in spinal surgery decreases blood loss and duration of hospital stay while not increasing the risk of side effects such as deep vein thrombosis and pulmonary embolism.Clinical Relevance The study aims to provide clinicians who operate on spine trauma with information on the use of tranexamic acid to decrease blood loss and related complications.Level of Evidence 1.