RT Journal Article
SR Electronic
T1 Osteoimmunology: Interactions With the Immune System in Spinal Fusion
JF International Journal of Spine Surgery
JO Int J Spine Surg
FD International Society for the Advancement of Spine Surgery
SP 8556
DO 10.14444/8556
A1 Bergin, Stephen M.
A1 Crutcher, Clifford L.
A1 Keeler, Carolyn
A1 Rocos, Brett
A1 Haglund, Michael M.
A1 Michael Guo, H.
A1 Gottfried, Oren N.
A1 Richardson, William J.
A1 Than, Khoi D.
YR 2023
UL https://www.ijssurgery.com/content/early/2023/11/10/8556.abstract
AB Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the osteogenic, osteoconductive, and osteoinductive properties of bone grafts and substitutes and ultimately influences the success of spinal fusion. Macrophages have emerged as important cells for coordinating the immune response following spinal fusion surgery, and macrophage-derived cytokines impact each phase of bone graft healing. This review explores the cellular and molecular immune processes that regulate bone homeostasis and healing during spinal fusion.