PT  - JOURNAL ARTICLE
AU  - Hirsch, Brandon P.
AU  - Sossamon, Jake
AU  - Khan, Monis A.
AU  - Reitman, Charles
AU  - Lawrence, James P.
AU  - Glaser, John
AU  - Chun, Rebecca
AU  - Gerald, Brittany
AU  - Baron, Eli
AU  - Goldstein, Theodore
AU  - Baaj, Ali A.
AU  - Patrick Johnson, J.
AU  - Elojeimy, Saeed
AU  - Ravinsky, Robert A.
TI  - Applications of SPECT/CT in the Evaluation of Spinal Pathology: A Review
AID  - 10.14444/8552
DP  - 2024 Feb 01
TA  - International Journal of Spine Surgery
PG  - 9--23
VI  - 18
IP  - 1
4099  - https://www.ijssurgery.com/content/18/1/9.short
4100  - https://www.ijssurgery.com/content/18/1/9.full
SO  - Int J Spine Surg2024 Feb 01; 18
AB  - Background Accurate identification of pain generators in the context of low back and spine-related pain is crucial for effective treatment. This review aims to evaluate the potential usefulness of single photon emission computed tomography with computed tomography (SPECT/CT) as an imaging modality in guiding clinical decision-making.Methods A broad scoping literature review was conducted to identify relevant studies evaluating the use of SPECT/CT in patients with spine-related pain. Studies were reviewed for their methodology and results.Results SPECT/CT appears to have advantages over traditional modalities, such as magnetic resonance imaging and CT, in certain clinical scenarios. It may offer additional information to clinicians and improve the specificity of diagnosis. However, further studies are needed to fully assess its diagnostic accuracy and clinical utility.Conclusions SPECT/CT is a promising imaging modality in the evaluation of low back pain, particularly in cases where magnetic resonance imaging and CT are inconclusive or equivocal. However, the current level of evidence is limited, and additional research is needed to determine its overall clinical relevance.Clinical Relevance SPECT/CT may have a significant impact on clinical decision-making, particularly in cases in which traditional imaging modalities fail to provide a clear diagnosis. Its ability to improve specificity could lead to more targeted and effective treatment for patients with spinal pathology.Level of Evidence 4.