RT Journal Article SR Electronic T1 Applications of SPECT/CT in the Evaluation of Spinal Pathology: A Review JF International Journal of Spine Surgery JO Int J Spine Surg FD International Society for the Advancement of Spine Surgery SP 9 OP 23 DO 10.14444/8552 VO 18 IS 1 A1 Hirsch, Brandon P. A1 Sossamon, Jake A1 Khan, Monis A. A1 Reitman, Charles A1 Lawrence, James P. A1 Glaser, John A1 Chun, Rebecca A1 Gerald, Brittany A1 Baron, Eli A1 Goldstein, Theodore A1 Baaj, Ali A. A1 Patrick Johnson, J. A1 Elojeimy, Saeed A1 Ravinsky, Robert A. YR 2024 UL https://www.ijssurgery.com/content/18/1/9.abstract AB Background Accurate identification of pain generators in the context of low back and spine-related pain is crucial for effective treatment. This review aims to evaluate the potential usefulness of single photon emission computed tomography with computed tomography (SPECT/CT) as an imaging modality in guiding clinical decision-making.Methods A broad scoping literature review was conducted to identify relevant studies evaluating the use of SPECT/CT in patients with spine-related pain. Studies were reviewed for their methodology and results.Results SPECT/CT appears to have advantages over traditional modalities, such as magnetic resonance imaging and CT, in certain clinical scenarios. It may offer additional information to clinicians and improve the specificity of diagnosis. However, further studies are needed to fully assess its diagnostic accuracy and clinical utility.Conclusions SPECT/CT is a promising imaging modality in the evaluation of low back pain, particularly in cases where magnetic resonance imaging and CT are inconclusive or equivocal. However, the current level of evidence is limited, and additional research is needed to determine its overall clinical relevance.Clinical Relevance SPECT/CT may have a significant impact on clinical decision-making, particularly in cases in which traditional imaging modalities fail to provide a clear diagnosis. Its ability to improve specificity could lead to more targeted and effective treatment for patients with spinal pathology.Level of Evidence 4.