RT Journal Article SR Electronic T1 Four-Level Cervical Disc Arthroplasty JF International Journal of Spine Surgery JO Int J Spine Surg FD International Society for the Advancement of Spine Surgery SP 8603 DO 10.14444/8603 A1 Chang, Hsuan-Kan A1 Chang, Chih-Chang A1 Tu, Tsung-Hsi A1 Kuo, Yi-Hsuan A1 Wu, Ching-Lan A1 Yeh, Mei-Yin A1 Kuo, Chao-Hung A1 Ko, Chin-Chu A1 Fay, Li-Yu A1 Huang, Wen-Cheng A1 Wu, Jau-Ching YR 2024 UL https://www.ijssurgery.com/content/early/2024/05/20/8603.abstract AB Background Multilevel anterior cervical discectomy and fusion inevitably yields a higher chance of pseudarthrosis or require more reoperations than single-level procedures. Therefore, multilevel cervical disc arthroplasty (CDA) could be an alternative surgery for cervical spondylosis, as it (particularly 3- and 4-level CDA) could preserve more functional motility than single-level disc diseases. This study aimed to investigate the clinical and radiological outcomes of 4-level CDA, a relatively infrequently indicated surgery.Methods The medical records of consecutive patients who underwent 4-level CDA were retrospectively reviewed. These highly selected patients typically had multilevel disc herniations with mild spondylosis. The inclusion criteria were symptomatic cervical spondylotic myelopathy, radiculopathy, or both, that were medically refractory. The clinical outcomes were assessed. The radiographic outcomes, including global and individual segmental range of motion (ROM) at C3-7, and any complications were also analyzed.Results Data from a total of 20 patients (mean age: 56 ± 8 years) with an average follow-up of 34 ± 20 months were analyzed. All patients reported improved clinical outcomes compared with that of preoperation, and the ROMs at C3-7 were not only preserved but also trended toward an increase (35 ± 8 vs 37 ± 10 degrees, pre- vs postoperation, P = 0.271) after the 4-level CDA. However, global cervical alignment remained unchanged. There was one permanent C5 radiculopathy, but no other neurological deteriorations or any reoperations occurred.Conclusion For these rare but unique indications, 4-level CDA yielded clinical improvement and preserved segmental motility with low rates of complications. Four-level CDA is a safe and effective surgery, maintaining the ROM in patients with primarily disc herniations and mild spondylosis.Clinical Relevance For patients with mild spondylosis, whose degeneration at the cervical spine is not so severe, CDA is more suitable.Level of Evidence 4.