PT  - JOURNAL ARTICLE
AU  - Darren R. Lebl
AU  - Kathleen N. Meyers
AU  - Franziska C.S. Altorfer
AU  - Hamidreza Jahandar
AU  - Theresa J.C. Pazionis
AU  - Joseph Nguyen
AU  - Patrick F. O’Leary
AU  - Timothy M. Wright
TI  - Biomechanical Motion Changes in Adjacent and Noncontiguous Segments Following Single-Level Anterior Cervical Discectomy and Fusion: A Computed Tomography–Based 3D Motion Capture Study
AID  - 10.14444/8605
DP  - 2024 Jun 06
TA  - International Journal of Spine Surgery
PG  - 8605
4099  - https://www.ijssurgery.com/content/early/2024/06/05/8605.short
4100  - https://www.ijssurgery.com/content/early/2024/06/05/8605.full
AB  - Background Anterior cervical discectomy and fusion (ACDF) is known to elicit adverse biomechanical effects on immediately adjacent segments; however, its impact on the kinematics of the remaining nonadjacent cervical levels has not been understood. This study aimed to explore the biomechanical impact of ACDF on kinematics beyond the immediate fusion site. We hypothesized that compensatory motion following single-level ACDF is not predictably distributed to adjacent segments due to compensation from noncontiguous levels.Methods Six fresh-frozen cervical spines (C2–T1) underwent fluoroscopic screening and sagittal and coronal reformats from computed tomography scans and were utilized to grade segmental degeneration. Each specimen was tested to 30° of flexion and extension intact and following single-level ACDF at the C5–C6 level. The motions of each vertebral body were tracked using 3-dimensional (3D) motion capture into an inverse kinematics model, facilitating correlations between the 3D reconstruction from computed tomography images and the 3D motion capture data. This model was used to calculate each level’s flexion/extension range of motion (ROM).Results Single-level fusion at the C5–C6 level across all specimens resulted in a significant motion reduction of −6.8° (P = 0.002). No significant change in ROM occurred in the immediate adjacent segments C4–C5 (P = 0.07) or C6–C7 (P = 0.15). Hypermobility was observed in 2 specimens (33%) exclusively in adjacent segments. In contrast, the other 4 spines (66%) displayed hypermobility at noncontiguous segments. Hypermobility occurred in 42% (5/12) of the adjacent segments, 28% (5/18) of the noncontiguous segments, and 50% (3/6) of the cervicothoracic segments.Conclusion Single-level ACDF impacts ROM beyond adjacent segments, extending to noncontiguous levels. Compensatory motion, not limited to adjacent levels, may be influenced by degenerative changes in noncontiguous segments. Surprisingly, hypermobility may not occur in adjacent segments after ACDF.Clinical Relevance Overall, the multifaceted biomechanical effects of ACDF underscore the need for a comprehensive understanding of cervical spine dynamics beyond immediate adjacency, and it needs to be taken into consideration when planning single-level ACDF.Level of Evidence 4.