PT  - JOURNAL ARTICLE
AU  - Chi, Jialun
AU  - Woods, Kate S.
AU  - Vengsarkar, Ved A.
AU  - Xu, Zhiwen
AU  - Yang, Hanzhi
AU  - Kumar, Abhishek
AU  - Zhang, Yi
AU  - Zhang, Zhichang
AU  - Wang, Jesse
AU  - Labaran, Lawal
AU  - Jin, Li
AU  - Li, Xudong
TI  - Short- and Mid-Term Outcomes Following ALIF and TLIF in L5-S1 Isthmic Spondylolisthesis Patients
AID  - 10.14444/8696
DP  - 2025 Jan 13
TA  - International Journal of Spine Surgery
PG  - 8696
4099  - https://www.ijssurgery.com/content/early/2025/01/13/8696.short
4100  - https://www.ijssurgery.com/content/early/2025/01/13/8696.full
AB  - Background A limited number of studies have compared the outcomes of anterior lumbar interbody fusion (ALIF) to transforaminal lumbar interbody fusion (TLIF) for the treatment of isthmic spondylolisthesis. This study aims to compare postoperative complications between these two surgical approaches.Methods A retrospective review was performed using a large national database. The study population included all patients older than 18 years who underwent single-level ALIF or TLIF with a diagnosis of L5 to S1 isthmic spondylolisthesis. A 1:2 propensity score was used to match ALIF and TLIF cohorts for age, sex, and relevant comorbidities, including smoking status. Multivariate logistic regression was used to compare 3-month and 2-year medical and surgical complications, including 5-year reoperation rates.Results Five hundred and seventy-eight ALIF patients were paired with 1,156 TLIF patients following the match. The analysis revealed a higher 3-month ileus rate in ALIF patients (P = 0.009) and a lower, though not significant difference in, reoperation rate for ALIF within 2 years at 7.1% compared with TLIF at 7.7% (P = 0.696). Five-year reoperation rates were comparable (9.5% vs 10.8%; P = 0.612).Conclusions Aside from the increased rate of ileus in the ALIF group, there was no significant difference in both short- and mid-term complications, including overall reoperation rate, between the 2 techniques. Spine surgeons should select the optimal technique for a given patient.Clinical Relevance ALIF and TLIF offer comparable mid-term postoperative outcomes for treating 1-level L5/S1 isthmic spondylolisthesis.Level of Evidence 3.