PT  - JOURNAL ARTICLE
AU  - KRUTKO, ALEKSANDR V.
AU  - SANGINOV, ABDUGAFUR J.
AU  - BAYKOV, EVGENII S.
TI  - Predictors of Treatment Success Following Limited Discectomy With Annular Closure for Lumbar Disc Herniation
AID  - 10.14444/7005
DP  - 2020 Feb 01
TA  - International Journal of Spine Surgery
PG  - 38--45
VI  - 14
IP  - 1
4099  - https://www.ijssurgery.com/content/14/1/38.short
4100  - https://www.ijssurgery.com/content/14/1/38.full
SO  - Int J Spine Surg2020 Feb 01; 14
AB  - Background Previous studies have demonstrated bone-anchored annular closure to significantly reduce reherniation and reoperation rates after lumbar discectomy in patients with large annular defects. It is important to identify the prognostic factors that may be associated with successful treatment. This study aimed to identify predictors of treatment success in patients with lumbar disc herniation treated with limited microdiscectomy supplemented by a bone-anchored annular closure device (ACD).Methods This study was a retrospective analysis of 133 consecutive patients with lumbar disc herniation treated with the ACD. Treatment success was defined as ≥24% improvement in visual analog scale (VAS) for back pain, ≥39% improvement in VAS leg pain, and ≥33% in the Oswestry Disability Index (ODI), with the raw ODI score ≤48. Success was calculated at 3, 6, and 12 months after surgery. Potentially predictive outcomes included patient characteristics, operative data, and imaging outcomes, such as disc, facet, and end plate morphology. Logistic regression was used to determine the significant predictive factors for treatment success.Results After 3, 6, and 12 months, 97 of 131 (74%), 104 of 129 (81%), and 112 of 126 (89%) patients, respectively, achieved the success criteria. At 3 months follow-up, a higher proportion of younger (17–40 years) versus older (41–65 years) patients met the success criteria (P = .025). On the basis of logistic regression, the following factors were significantly associated with treatment success at 1 or more of the follow-up time points: sex (male), lower body mass index, higher baseline pain and ODI scores, lower grade preoperative disc degeneration, and the absence of a postoperative complication. The rates of index-level recurrent herniation and reoperation were 1.5% and 3.0%, respectively.Conclusions This real-world evidence supports a promising benefit-risk profile for augmenting limited microdiscectomy with a bone-anchored ACD and provides some insights into the patient populations that may have a greater chance of realizing significant improvements in pain and function.Level of Evidence 2 (Cohort study).