Review of studies comparing DBM to other bone grafts or implants in cervical spine.
| Study | Design | Patient Population | Groups (No. of Patients) | Follow-Up, mo | Fusion Rates | Other Outcomes | Notes |
| Yi et al, 201537 | Prospective and randomized | ACDF | PEEK and HA-DBM (43) vs HA-BTP (42) | 12 | 87% HA-DBM vs 72% HA-BTP (P = 0.16) | No difference in neck disability score or infection | Bonion |
| Xie et al, 201538 | Prospective and randomized | ACDF | PEEK and calcium sulfate and DBM (35) vs autologous ICBG (33) | 24 | 94% DBM vs 100% ICBG (P not reported) | OsteoSet2 DBM | |
| An et al, 199535 | Prospective | Uninstrumented anterior cervical fusion | DBM with freeze- dried allograft (39) vs autologous ICBG (38) | 12 | Higher rates of pseudoarthrosis with DBM/allograft and higher rates of graft collapse | Grafton DBM Gel | |
| Lee et al, 201936 | Retrospective | Instrumented ACDF | DBM (24) vs autologous ICBG (17) | 24 | 94% DBM vs 96% ICBG (P = 0.66) | Orthoblast II |
Abbreviations: ACDF, anterior cervical discectomy and fusion; BTP, β-tricalcium phosphate; DBM, demineralized bone matrix; HA, hydroxyapatite; ICBG, iliac crest bone graft; PEEK, polyetheretherketone.