Input parameters used in the health economic model.
Parameters | Distribution | Base Case | Range | References |
Annual transition probabilities | ||||
Well state | ||||
To index revision (LLIF) | Beta | 0.0169 | 0.015–0.019 | [14] |
To adjacent revision (LLIF) | Beta | 0.0088 | 0.008–0.010 | [15] |
To index revision (PLIF) | Beta | 0.0203 | 0.018–0.022 | [16] |
To adjacent revision (PLIF) | Beta | 0.0237 | 0.021–0.026 | [17] |
Index revision state | ||||
To well (LLIF) | Beta | 0.0979 | 0.088–0.108 | [14] |
To adjacent revision (LLIF) | Beta | 0.0088 | 0.008–0.010 | [15] |
To well (PLIF) | Beta | 0.0203 | 0.018–0.022 | [16] |
To adjacent revision (PLIF) | Beta | 0.0237 | 0.021–0.026 | [17] |
Adjacent revision state | ||||
To index revision (LLIF) | Beta | 0.0005 | 0.0005–0.0006 | [15], Expert opinion |
To index revision (PLIF) | Beta | 0.0006 | 0.0005–0.0007 | [17], Expert opinion |
Utilities | ||||
LLIF, Well (3 mo) | Beta | 0.874 | 0.817–0.931 | Primary data |
LLIF, Complication (3 mo) | Beta | 0.778 | 0.652–0.904 | Primary data |
LLIF, Well (12th mo) | Beta | 0.874 | 0.817–0.931 | Primary data |
LLIF, Well (>12th mo) | Beta | 0.854 | 0.705–0.907 | Primary data |
LLIF, Index revision (>12th mo) | Beta | 0.671 | 0.604–0.738 | [5] |
LLIF, Adjacent revision (>12th mo) | Beta | 0.703 | 0.633–0.773 | [5] |
PLIF, Well (3 mo) | Beta | 0.886 | 0.857–0.915 | Primary data |
PLIF, Complication (3 mo) | Beta | 0.870 | 0.821–0.919 | Primary data |
PLIF, Well (12th mo) | Beta | 0.886 | 0.857–0.915 | Primary data |
PLIF, Well (>12th mo) | Beta | 0.882 | 0.856–0.907 | Primary data |
PLIF, Index revision (>12th mo) | Beta | 0.646 | 0.581–0.711 | [5] |
PLIF, Adjacent revision (>12th mo) | Beta | 0.679 | 0.611–0.747 | [5] |
Costs of treatment, USD/y | ||||
Total cost of well (LLIF) | Gamma | 175 | 157–192 | Primary data |
Total cost of index revision (LLIF) | Gamma | 3,665 | 3,299–4,032 | Primary data |
Total cost of adjacent revision (LLIF) | Gamma | 7,062 | 6,356–7,768 | Primary data |
Total cost of well (PLIF) | Gamma | 175 | 157–192 | Primary data |
Total cost of index revision (PLIF) | Gamma | 3,462 | 3,116–3,808 | Primary data |
Total cost of adjacent revision (PLIF) | Gamma | 4,791 | 4,312–5,270 | Primary data |
PEEK (LLIF) | Gamma | 1,713 | 1,542–1,885 | Primary data |
PEEK (PLIF) | Gamma | 529 | 477–582 | Primary data |
Tricalcium phosphate | Gamma | 140 | 126–154 | Primary data |
Posterior spinal screws (LLIF) | Gamma | 1,544 | 1,390–1,699 | Primary data |
Posterior spinal screws (PLIF) | Gamma | 800 | 720–880 | Primary data |
Direct non-medication costs, USD/visit | ||||
Food OPD | Gamma | 13 | 13–13 | [20] |
Transportation | Gamma | 64 | 64–65 | [20] |
Abbreviations: IPD, inpatient department; LLIF, lateral lumbar interbody fusion; OPD, outpatient department; PEEK, polyetheretherketone; PLIF, posterior lumbar interbody fusion.