Table 4

Complication rates in PLF patients starting NSAIDs use <72 h with different dispensing intervals.

Complication	NSAIDs Days Dispensed (1–30 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	452	0.803	0.494	1.306	0.376
Pseudoarthrodesis and hardware failure	47,754	452	1.229	0.981	1.538	0.072
Wound complications	47,754	452	0.571	0.391	0.832	0.004

Complication	NSAIDs Days Dispensed (31–90 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	150	0.708	0.290	1.729	0.449
Pseudoarthrodesis and hardware failure	47,754	150	1.077	0.740	1.568	0.698
Wound complications	47,754	150	0.857	0.494	1.487	0.583

Complication	NSAIDs Days Dispensed (91–180 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	82	1.053	0.385	2.880	0.919
Pseudoarthrodesis and hardware failure	47,754	82	1.805	0.998	3.266	0.051
Wound complications	47,754	82	1.026	0.513	2.053	0.941

Complication	NSAIDs Days Dispensed (181–365 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	145	1.042	0.487	2.229	0.916
Pseudoarthrodesis and hardware failure	47,754	145	1.110	0.756	1.631	0.594
Wound complications	47,754	145	0.683	0.369	1.265	0.225

Complication	NSAIDs Days Dispensed (366–720 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	44	1.503	0.465	4.857	0.496
Pseudoarthrodesis and hardware failure	47,754	44	0.907	0.467	1.762	0.773
Wound complications	47,754	44	0.833	0.298	2.328	0.727

Abbreviations: NSAIDs, nonsteroidal anti-inflammatory drugs; PLF, posterior lumbar fusion.
Note: Bold values indicate a significance at a Bonferroni-adjusted P value of ≤0.01