Table 6

Complication rates in PLF patients starting NSAIDs use 72 h to 90 d with different dispensing intervals.

Complication	NSAIDs Days Dispensed (1–30 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	3096	1.313	1.125	1.532	0.001
Pseudoarthrodesis and hardware failure	47,754	3096	0.984	0.906	1.070	0.712
Wound complications	47,754	3096	1.427	1.286	1.583	<0.001

Complication	NSAIDs Days Dispensed (31–90 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	2074	0.899	0.723	1.119	0.342
Pseudoarthrodesis and hardware failure	47,754	2074	1.014	0.916	1.122	0.790
Wound complications	47,754	2074	1.115	0.973	1.278	0.117

Complication	NSAIDs Days Dispensed (91–180 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	1616	0.916	0.717	1.170	0.483
Pseudoarthrodesis and hardware failure	47,754	1616	1.126	1.001	1.266	0.048
Wound complications	47,754	1616	0.953	0.810	1.122	0.564

Complication	NSAIDs Days Dispensed (181–365 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	3408	0.893	0.751	1.062	0.201
Pseudoarthrodesis and hardware failure	47,754	3408	1.212	1.114	1.317	<0.001
Wound complications	47,754	3408	1.002	0.895	1.121	0.977

Complication	NSAIDs Days Dispensed (366–720 d)
Complication	N Control	N Intervention	OR	CI Lower	CI Upper	P
Readmission	47,754	332	0.972	0.578	1.634	0.914
Pseudoarthrodesis and hardware failure	47,754	332	1.228	0.945	1.596	0.124
Wound complications	47,754	332	1.173	0.845	1.629	0.341

Abbreviations: NSAIDs, nonsteroidal anti-inflammatory drugs; PLF, posterior lumbar fusion.
Note: Bold values indicate a significance at a Bonferroni-adjusted P value of ≤0.01.