Abstract
The main components (Ti, V, Cr, Co, Ni, and Mo) of metallic alloys currently used in hip and knee articular prostheses have been simultaneously determined in human whole blood and urine of implanted people by a (HR)-ICP–MS method previously developed in our laboratory. The determination of those elements has been carried out in patients with knee and hip prosthesis and in a group of pre-operation patients without any metallic device in their bodies, used as controls, demonstrating the usefulness of this technique to perform multielement analysis at ppt levels in complex matrices. The concentrations of V, Cr, Co, Ni, and Mo in urine and blood of implanted people turned out to be very similar to those obtained in control patients. However, raised Ti levels could be found both in urine and blood of patients with articular prostheses made or coated with a titanium alloy (Ti6Al4V).
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Acknowledgements
The authors gratefully acknowledge the financial support provided by Acuña y Fombona S.A, FICYT (project PC-SPV01–06) and the Ministry of Science and Technology of Spain (project MCT-03-BQU-04671). Help from Meike Hamester and Torsten Lindemann of Thermo Fisher Scientific and Andreas Klügel and Heike Anders of the Department of Petrology of the Oceanic Crust of the University of Bremen is specially acknowledged.
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Sarmiento-González, A., Marchante-Gayón, J.M., Tejerina-Lobo, J.M. et al. High-resolution ICP–MS determination of Ti, V, Cr, Co, Ni, and Mo in human blood and urine of patients implanted with a hip or knee prosthesis. Anal Bioanal Chem 391, 2583–2589 (2008). https://doi.org/10.1007/s00216-008-2188-4
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DOI: https://doi.org/10.1007/s00216-008-2188-4