Role of complement in alloimmunization and hyperhemolysis

S Chonat, A Mener, H Verkerke… - Current opinion in …, 2020 - journals.lww.com
Recent studies suggest that complement can regulate a wide variety of processes germane
to hematology, from transfusion complications to baseline hemolysis in patients with SCD. …

Daratumumab (anti-CD38) induces loss of CD38 on red blood cells

…, CM Arthur, L Thompson, A Mener… - Blood, The Journal …, 2017 - ashpublications.org
Amanda Mener, Amanda Mener … Arthur, Louisa Thompson, Amanda Mener, Seema R.
Patel, Marianne Yee, Ross M. Fasano, Cassandra D. …

Innate immunity against molecular mimicry: examining galectin‐mediated antimicrobial activity

CM Arthur, SR Patel, A Mener, NA Kamili… - …, 2015 - Wiley Online Library
Adaptive immunity provides the unique ability to respond to a nearly infinite range of antigenic
determinants. Given the inherent plasticity of the adaptive immune system, a series of …

Antigen density dictates immune responsiveness following red blood cell transfusion

…, NH Smith, A Bennett, NA Kamili, A Mener… - The Journal of …, 2017 - journals.aai.org
Although RBC transfusion can result in the development of anti-RBC alloantibodies that
increase the probability of life-threatening hemolytic transfusion reactions, not all patients …

[HTML][HTML] Complement serves as a switch between CD4+ T cell–independent and–dependent RBC antibody responses

A Mener, SR Patel, CM Arthur, S Chonat, A Wieland… - JCI insight, 2018 - ncbi.nlm.nih.gov
RBC alloimmunization represents a significant immunological challenge for patients requiring
lifelong transfusion support. The majority of clinically relevant non-ABO (H) blood group …

CyberKnife stereotactic radiosurgery for the treatment of intramedullary spinal cord metastases

A Veeravagu, RE Lieberson, A Mener, YR Chen… - Journal of Clinical …, 2012 - Elsevier
Spinal cord intramedullary metastases are uncommon and treatment options are limited.
We reviewed our experience treating these lesions with radiosurgery to assess safety and …

[HTML][HTML] Complement component 3 negatively regulates antibody response by modulation of red blood cell antigen

A Mener, CM Arthur, SR Patel, J Liu… - Frontiers in …, 2018 - frontiersin.org
Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for
future transfusion, directly leading to increased morbidity and mortality in transfusion-…

Antibody-mediated immune suppression by antigen modulation is antigen-specific

CL Maier, A Mener, SR Patel, RP Jajosky… - Blood …, 2018 - ashpublications.org
Alloantibodies developing after exposure to red blood cell (RBC) alloantigens can complicate
pregnancy and transfusion therapy. The only method currently available to actively inhibit …

Recipient priming to one RBC alloantigen directly enhances subsequent alloimmunization in mice

…, S Chonat, CM Arthur, PE Zerra, A Mener… - Blood …, 2018 - ashpublications.org
Individuals that become immunized to red blood cell (RBC) alloantigens can experience an
increased rate of antibody formation to additional RBC alloantigens following subsequent …

[HTML][HTML] Prosthetic joint infection trends at a dedicated orthopaedics specialty hospital

RP Runner, A Mener, JR Roberson… - Advances in …, 2019 - hindawi.com
Introduction. Historically, a majority of prosthetic joint infections (PJIs) grew Gram-positive
bacteria. While previous studies stratified PJI risk with specific organisms by patient …