Nuclear receptors are of integral importance in carcinogenesis. Manipulation of classic
ligand-activated nuclear receptors, such as estrogen receptor blockade in breast cancer, is an …

Inflammation is paradoxical; it is essential for protection following biological, chemical or
physical stimuli, but inappropriate or misdirected inflammation is responsible for tissue injury in …

Statement of findings Acute-phase serum amyloid A (A-SAA) is a major component of the
acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is …

Objective To evaluate the regulation of acute‐phase serum amyloid A (A‐SAA) production in
inflamed synovial tissue, and to elucidate a possible pathophysiologic role in the induction …

The present study was designed to examine the role of the nurr1/nur77 subfamily of nuclear
receptor transcription factors in the regulation of the hypothalamic/pituitary/adrenal axis at …

Background During the current COVID-19 health crisis virtual geriatric clinics have become
increasingly utilised to complete outpatient consultations, although concerns exist about …

Modulation of the NURR subfamily of nuclear receptors may be an important mechanism
regulating pathways associated with inflammatory joint disease. We examined the signaling …

Corticotropin‐releasing hormone (CRH) coordinates the systemic stress response via
hypothalamic‐pituitary‐adrenal (HPA) axis activation with subsequent modulation of the …

Background Virtual fracture clinics are an alternative to the traditional model of fracture care.
Since their introduction in 2011, they have become increasingly used in the United …

Appropriate innate and adaptive immune responses are essential for protection and resolution
against chemical, physical or biological insults. Immune cell polarization is fundamental …