Background and purpose For prosthetic joint-associated infection (PJI), a regimen of debridement,
antibiotics, irrigation, and retention of the prosthesis (DAIR) is generally accepted for …

Background The use of radiotherapy in osteosarcoma (OS) is controversial due to its
radioresistance. OS patients currently treated with radiotherapy generally are inoperable, have …

Study Design. Classic cases of Scheuermann disease in male monozygotic twins are reported.
Objectives. To report classic cases of Scheuermann disease or Scheuermann kyphosis …

Despite improvements in treatment regimens for osteosarcoma (OS) patients, survival rate
has not increased over the last two decades. New treatment modalities are therefore …

Background Oncolytic viruses are promising anticancer agents because they selectively kill
cancer cells and multiply within a tumor. Their oncolytic potency might be improved by …

Strategies to treat cancer by restoring p53 tumor suppressor functions are being actively
investigated. These approaches range from expressing an exogenous p53 gene in p53 mutant …

Study Design. A case of disseminated Nocardia farcinica infection with spine involvement is
reported. Objective. To describe the first case of Nocardia farcinica spinal osteomyelitis, and …

Study Design. Cohort study. Objective. To analyze long-term clinical and radiological
outcomes of surgically treated Scheuermann patients. Summary of Background Data. Long-term …

A 59-year-old woman with a painful right knee that became locked in extension after a trivial
trauma was seen at the emergency room. This was caused by unloaded hyperextension in …

Virotherapy of cancer using oncolytic adenoviruses has shown promise in both preclinical
and clinical settings. One important challenge to reach the full therapeutic potential of …