Degenerative disc disease is implicated in the pathogenesis of many painful conditions of
the back, chief among which is low back pain. Acute and/or chronic low back pain (A/CLBP) …

Many early stage interventions for intervertebral disc degeneration are under development
involving injection of a biomaterial into the affected tissue. Due to the complex mechanical …

Abstract Nucleus Pulposus (NP) Replacement is a developing surgical methodology for the
treatment of pathology related to degeneration of intervertebral discs (IVDs). This article …

Abstract Background Nucleus replacement devices (NRDs) are not routinely used in clinic,
predominantly due to the risk of device expulsion. Rigorous in vitro testing may enable …

Study Design. A prospective, nonrandomized multicenter study of lumbar disc nucleus
replacement using the DASCOR Disc Arthroplasty Device. An interim analysis of clinical …

This review aimed to summarize the recent advances and challenges in the field of
regenerative therapies for lumbar disc degeneration. The current first-line treatment options …

Design: cadaveric spine nucleus replacement study. Objective: determining Bionate 80A
nucleus replacement biomechanics in cadaveric spines. Methods: in cold preserved spines …

BACKGROUND CONTEXT: Degenerative disc disease is commonly a multilevel pathology
with varying deterioration severity. The use of fusion on multiple levels can significantly …

A detailed three-dimensional solid model of the full cervical spine (C1–C7 levels) and the
finite element analysis method were used to investigate the extent of changes in various …

Study Design. A validated L3–L4 nonlinear finite element model was used to evaluate strain
and pressure in the surrounding structures for 4 nucleus replacement technologies …