[HTML][HTML] Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration

…, AA Cole, LM Breakwell, ALR Michael… - Arthritis research & …, 2014 - Springer
Introduction The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve
fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, …

(ii) An update on fracture healing and non-union

PJ Harwood, JB Newman, ALR Michael - Orthopaedics and Trauma, 2010 - Elsevier
The basic science underlying the process of bone healing has been a topic of intense research
activity over the past 50 years. Increasing understanding of events on a molecular level …

[HTML][HTML] The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc

KLE Phillips, N Chiverton, ALR Michael… - Arthritis research & …, 2013 - Springer
Introduction The aims of these studies were to identify the cytokine and chemokine expression
profile of nucleus pulposus (NP) cells and to determine the relationships between NP cell …

[HTML][HTML] Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc

ALA Binch, AA Cole, LM Breakwell, ALR Michael… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Nerve and blood vessel ingrowth during intervertebral disc degeneration, is thought to be a
major cause of low back pain, however the regulation of this process is poorly understood. …

A survey of current controversies in scoliosis surgery in the United Kingdom

ALR Michael, PR Loughenbury, AS Rao, RA Dunsmuir… - Spine, 2012 - journals.lww.com
Study Design. A 10-point questionnaire was constructed to identify the philosophy of surgeons
on various aspects of scoliosis surgery, such as choice of implant, bone graft, autologous …

Prevalence and significance of vitamin D deficiency in patients undergoing corrective surgery for adolescent idiopathic scoliosis

…, LM Breakwell, AA Cole, ALR Michael - International Journal of …, 2022 - ijssurgery.com
Background The exact etiology of adolescent idiopathic scoliosis (AIS) is unknown, but
recently, vitamin D has been suggested to be of importance in the pathophysiology of AIS. This …

[HTML][HTML] Polyamines in eukaryotes, bacteria, and archaea

AJ Michael - Journal of Biological Chemistry, 2016 - ASBMB
Polyamines are primordial polycations found in most cells and perform different functions in
different organisms. Although polyamines are mainly known for their essential roles in cell …

Biosynthesis of polyamines and polyamine-containing molecules

AJ Michael - Biochemical Journal, 2016 - portlandpress.com
Polyamines are evolutionarily ancient polycations derived from amino acids and are pervasive
in all domains of life. They are essential for cell growth and proliferation in eukaryotes …

A Novel Polyamine Acyltransferase Responsible for the Accumulation of Spermidine Conjugates in Arabidopsis Seed

…, K Elliott, SA Fairhurst, C Martin, AJ Michael - The Plant …, 2009 - academic.oup.com
Hydroxycinnamic acid amides are a class of secondary metabolites distributed widely in
plants. We have identified two sinapoyl spermidine derivatives, N-((4′-O-glycosyl)-sinapoyl),N…

Convergent evolution in the BAHD family of acyl transferases: identification and characterization of anthocyanin acyl transferases from Arabidopsis thaliana

…, M Yamazaki, P Bailey, A Parr, AJ Michael… - The Plant …, 2007 - Wiley Online Library
Members of the BAHD family of plant acyl transferases are very versatile catalytically, and
are thought to be able to evolve new substrate specificities rapidly. Acylation of anthocyanins …