The endocytic pathway in microglia during health, aging and Alzheimer's disease
S Solé-Domènech, DL Cruz, E Capetillo-Zarate… - Ageing research …, 2016 - Elsevier
Microglia, the main phagocytes of the central nervous system (CNS), are involved in the
surveillance and maintenance of nervous tissue. During normal tissue homeostasis, microglia …
surveillance and maintenance of nervous tissue. During normal tissue homeostasis, microglia …
Full-body analysis of age-adjusted alignment in adult spinal deformity patients and lower-limb compensation
CM Jalai, DL Cruz, BG Diebo, G Poorman, R Lafage… - Spine, 2017 - journals.lww.com
Study Design. Single-center retrospective review. Objective. The present study evaluates the
effect of increasing spinal deformity deviation from age-adjusted alignment ideals on lower …
effect of increasing spinal deformity deviation from age-adjusted alignment ideals on lower …
The impact of obesity on compensatory mechanisms in response to progressive sagittal malalignment
Background Context Obesity's impact on standing sagittal alignment remains poorly
understood, especially with respect to the role of the lower limbs. Given energetic expenditure in …
understood, especially with respect to the role of the lower limbs. Given energetic expenditure in …
Full-body radiographic analysis of postoperative deviations from age-adjusted alignment goals in adult spinal deformity correction and related compensatory …
PG Passias, CM Jalai, BG Diebo, DL Cruz… - International journal of …, 2019 - ijssurgery.com
Background: Full-body stereographs for adult spinal deformity (ASD) have enhanced global
deformity and lower-limb compensation associations. The advent of age-adjusted goals for …
deformity and lower-limb compensation associations. The advent of age-adjusted goals for …
2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease
…, O Wiest, X Xu, FD Porter, NH Pipalia, DL Cruz… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Niemann-Pick type C1 (NPC1) disease is a fatal neurovisceral disease for which there are
no FDA approved treatments, though cyclodextrin (HPβCD) slows disease progression in …
no FDA approved treatments, though cyclodextrin (HPβCD) slows disease progression in …
A comparison of two different dosing protocols for tranexamic acid in posterior spinal fusion for spinal deformity: a prospective, randomized trial
K Verma, E Kohan, CP Ames, DL Cruz… - International journal of …, 2015 - ijssurgery.com
Background Multilevel spinal fusions have typically been associated with significant blood
loss. Previous studies have shown a reduction in blood loss with antifibrinolytics in both …
loss. Previous studies have shown a reduction in blood loss with antifibrinolytics in both …
Inhibition of histone deacetylases 1, 2, and 3 enhances clearance of cholesterol accumulation in Niemann-Pick C1 fibroblasts
Niemann-Pick disease type C1 (NPC1) is a rare genetic cholesterol storage disorder caused
by mutations in the NPC1 gene. Mutations in this transmembrane late endosome protein …
by mutations in the NPC1 gene. Mutations in this transmembrane late endosome protein …
Validation of the recently developed Total Disability Index: a single measure of disability in neck and back pain patients
DL Cruz, EW Ayres, MA Spiegel, LM Day… - … of Neurosurgery: Spine, 2019 - thejns.org
OBJECTIVE Neck and back pain are highly prevalent conditions that account for major
disability. The Neck Disability Index (NDI) and Oswestry Disability Index (ODI) are the two most …
disability. The Neck Disability Index (NDI) and Oswestry Disability Index (ODI) are the two most …
Realignment Planning in Adult Spinal Deformity: Formulas and Planning Tools.
T Protopsaltis, DL Cruz - Instructional Course Lectures, 2017 - europepmc.org
Adult spinal deformity is a complex pathologic process that has many etiologies and several
mechanisms of compensation. A complete understanding of spinopelvic alignment is …
mechanisms of compensation. A complete understanding of spinopelvic alignment is …
Imaging Adult Lumbar Scoliosis
DL Cruz, T Protopsaltis - Adult Lumbar Scoliosis: A Clinical Guide to …, 2017 - Springer
Radiographic assessment is an integral component of the evaluation and management of
lumbar scoliosis. Although lumbar deformity is relatively common, the complexity and …
lumbar scoliosis. Although lumbar deformity is relatively common, the complexity and …
