Background Among patients with a proximal vessel occlusion in the anterior circulation, 60
to 80% of patients die within 90 days after stroke onset or do not regain functional …

Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. …

Background— The Endovascular Treatment for Small Core and Proximal Occlusion Ischemic
Stroke (ESCAPE) trial used innovative imaging and aggressive target time metrics to …

Background Tandem occlusions of the extracranial carotid and intracranial carotid or middle
cerebral artery have a particularly poor prognosis without treatment. Several management …

Importance The benefits of endovascular thrombectomy (EVT) are time dependent. Prior
studies may have underestimated the time-benefit association because time of onset is …

Background and Purpose— Infarct in a new previously unaffected territory (INT) is a potential
complication of endovascular treatment. We applied a recently proposed methodology to …

Background and Purpose— Multimodal imaging in acute ischemic stroke defines the extent
of arterial collaterals, resultant penumbra, and associated infarct core, yet limitations abound…

Background and Purpose— The goal of reperfusion therapy in acute ischemic stroke is to limit
brain infarction. The objective of this study was to investigate whether the beneficial effect …

Background and Purpose: Fast infarct progression in acute ischemic stroke has a severe
impact on patient prognosis and benefit of endovascular thrombectomy. In this post hoc …

Background: Infarct in a new territory (INT) is a known complication of endovascular stroke
therapy. We assessed the incidence of INT, outcomes after INT, and the impact of concurrent …