Study design An in vivo study of the biologic and biomechanical consequences of static
compressive loading on the mouse tail intervertebral disc. Objectives To determine whether …

… Indeed, Lotz and Chin 6 found that apoptosis did not occur uniformly but was initially seen
… In the study of Lotz and Chin, 6 the discs were exposed to static compressive load for up to 7 …

This study explores the use of mesenchymal stem cells (MSCs) for intervertebral disc
regeneration. We used an in vivo model to investigate the feasibility of exogenous cell delivery, …

We have investigated the relationships between trabecular bone compressive strength and
elastic modulus and the directly measured apparent density and noninvasively measured CT …

A new musculoskeletal model for the lumbar spine is described in this paper. This model
features a rigid pelvis and sacrum, the five lumbar vertebrae, and a rigid torso consisting of a …

Study Design. An in vitro biomechanical study of C1–C2 posterior fusion techniques was
conducted using a cadaveric model. Objective. To investigate and compare the acute stability …

Disc degeneration is a chronic remodeling process that results in alterations of matrix
composition and decreased cellularity. This study tested the hypothesis that dynamic mechanical …

Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …

Study Design. An in vivo model was used to investigate the response of degenerated discs
to various exogenous growth factors. Objectives. To study growth factor-induced alterations …

… Palmer EI, Lotz JC. The effects of tissue level forces on the cells of the intervertebral disc. …
Palmer EI, Lotz JC. The time dependent role of cytokines in mechanically induced …