Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline

CJ Padilla, ME Harrigan, H Harris, JM Schwab… - Geroscience, 2021 - Springer
Pathological age-related loss of skeletal muscle strength and mass contribute to impaired
physical function in older adults. Factors that promote the development of these conditions …

Lesion level–dependent systemic muscle wasting after spinal cord injury is mediated by glucocorticoid signaling in mice

ME Harrigan, AR Filous, CP Vadala, A Webb… - Science Translational …, 2023 - science.org
An incomplete mechanistic understanding of skeletal muscle wasting early after spinal cord
injury (SCI) precludes targeted molecular interventions. Here, we demonstrated systemic …

[PDF][PDF] Discovery of stromal regulatory networks that suppress ras-sensitized epithelial cell proliferation

…, E Wheeler, X Tang, K Toth, M Lause, ME Harrigan… - Developmental cell, 2017 - cell.com
Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both
normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to …

[HTML][HTML] Assessing rat forelimb and hindlimb motor unit connectivity as objective and robust biomarkers of spinal motor neuron function

ME Harrigan, AR Filous, AP Tosolini, R Morris… - Scientific Reports, 2019 - nature.com
Sensitive and objective biomarkers of neuronal injury, degeneration, and regeneration can
help facilitate translation of experimental findings into clinical testing. Whereas measures of …

Demineralized Bone Matrix and Fibers in Spinal Fusion

JL Wang, RG Eaton, ME Harrigan, V Munjal… - International Journal of …, 2023 - ijssurgery.com
Formation of bony fusion after arthrodesis depends on osteoinduction, osteoconduction, and
osteogenesis. Traditionally, the patient’s own bone, or autograft, has been used to provide …

Correction to: profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline

CJ Padilla, ME Harrigan, H Harris, JM Schwab… - GeroScience, 2021 - Springer
Aged rats demonstrate significant deficits in neuromuscular junction transmission ab.
Repetitive nerve stimulation demonstrated significant reduction of compound muscle action …

Lesion level-dependent glucocorticoid dysregulation exacerbates systemic muscle wasting during the acute phase of paraplegic rodent spinal cord injury

ME Harrigan - 2022 - rave.ohiolink.edu
Recently an increased appreciation for the systemic consequences of spinal cord injury (SCI)
has re-emerged. These pathophysiological processes provide novel therapeutic targets, …

Novel stromal-derived oncogenic signals enhance Ras-mediated cell proliferation

M Harrigan - 2015 - kb.osu.edu
… Finally, I would like to thank my family, especially my parents Christopher Harrigan and
Heidi Beke-Harrigan, and friends for their unwavering support. I would not be where I am today, …

Ischemic stroke due to blunt traumatic cerebrovascular injury

MR Harrigan - Stroke, 2020 - Am Heart Assoc
354 Stroke January 2020 motion causing stretching of the artery, or a direct blow to the
artery, may produce intimal tears and expose subendothelial collagen, resulting in platelet …

Me, myself, and I: A systematic review of cystic fibrosis and self‐concept

M Harrigan, M Jessup, K Bennett… - Pediatric …, 2024 - Wiley Online Library
Given extensive pertinent disease factors and evolving medical treatments, this systematic
review explores qualitative and quantitative cystic fibrosis (CF) research surrounding self‐…