We have profiled, for the first time, an evolving human metastatic microenvironment by
measuring gene expression, matrisome proteomics, cytokine and chemokine levels, cellularity, …

We investigated the role of the chondrocyte primary cilium in mechanotransduction events
related to cartilage extracellular matrix synthesis. We generated conditionally immortalized …

Stem cells are undifferentiated cells that are capable of proliferation, self‐maintenance and
differentiation towards specific cell phenotypes. These processes are controlled by a variety …

The pathways by which chondrocytes of articular cartilage sense their mechanical environment
are unclear. Compelling structural evidence suggests that chondrocyte primary cilia are …

Abstract Changes in extracellular osmolality have been shown to alter gene expression
patterns and metabolic activity of various cell types, including chondrocytes. However, …

Ca 2+ signaling forms part of a possible mechanotransduction pathway by which chondrocytes
may alter their metabolism in response to mechanical loading. In this study, a well-…

Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

Mechanotransduction events in articular cartilage may be resolved into extracellular components
followed by intracellular signalling events, which finally lead to altered cell response. …

Isolated chondrocytes stained with fluo 4-AM and visualized using standard confocal
microscopy techniques exhibited Ca 2+ transients and oscillations. Decreasing the power of the …

To study the effects of compressive straining on muscle cell deformation and damage an in
vitro model system was developed. Myoblasts were seeded in agarose constructs and …