Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide
experiments. Here we present a significant update to one of the tools in this domain called …

Many patients with chronic pain do not obtain adequate relief or experience unacceptable
side effects from existing treatments. Moreover, even when clinical trials report positive …

Autosomal dominant periodic fever syndromes are characterized by unexplained episodes
of fever and severe localized inflammation. In seven affected families, we found six different …

A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain
Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical …

The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent
brain, generating thousands of olfactory bulb neurons every day 1 . If the adult human brain …

Mutations within the NALP3/cryopyrin/CIAS1 gene are responsible for three autoinflammatory
disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and CINCA. …

… McDermott, and Mitchel S. Berger … McDermott, Mitchel S. Berger Administrative support:
Mitchel S. Berger … McDermott, Mitchel S. Berger Final approval of manuscript: Justin S …

Context Despite reported success, surgery for pharmacoresistant seizures is often seen as a
last resort. Patients are typically referred for surgery after 20 years of seizures, often too late …

Object The value of extent of resection (EOR) in improving survival in patients with glioblastoma
multiforme (GBM) remains controversial. Specifically, it is unclear what proportion of …

Objective. To provide recommendations for the core outcome domains that should be considered
by investigators conducting clinical trials of the efficacy and effectiveness of treatments …