Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury

PCH Hsieh, VFM Segers, ME Davis, C MacGillivray… - Nature medicine, 2007 - nature.com
An emerging concept is that the mammalian myocardium has the potential to regenerate,
but that regeneration might be too inefficient to repair the extensive myocardial injury that is …

Loss of gut microbiota alters immune system composition and cripples postinfarction cardiac repair

…, P Chen, TA Hacker, FE Rey, TJ Kamp, PCH Hsieh - Circulation, 2019 - Am Heart Assoc
Background: The impact of gut microbiota on the regulation of host physiology has recently
garnered considerable attention, particularly in key areas such as the immune system and …

Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction

ME Davis, PCH Hsieh, T Takahashi… - Proceedings of the …, 2006 - National Acad Sciences
Strategies for cardiac repair include injection of cells, but these approaches have been
hampered by poor cell engraftment, survival, and differentiation. To address these shortcomings …

Anterior lumbar interbody fusion in comparison with transforaminal lumbar interbody fusion: implications for the restoration of foraminal height, local disc angle, lumbar …

PC Hsieh, TR Koski, BA O'Shaughnessy… - … of Neurosurgery: Spine, 2007 - thejns.org
Object A primary consideration of all spinal fusion procedures is restoration of normal anatomy,
including disc height, lumbar lordosis, foraminal decompression, and sagittal balance. …

FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction

FB Engel, PCH Hsieh, RT Lee… - Proceedings of the …, 2006 - National Acad Sciences
Mammalian cardiomyocytes have limited proliferation potential, and acutely injured mammalian
hearts do not regenerate adequately. Instead, injured myocardium develops fibrosis and …

[HTML][HTML] Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers

PCH Hsieh, ME Davis, J Gannon… - The Journal of …, 2006 - Am Soc Clin Investig
Endothelial cells can protect cardiomyocytes from injury, but the mechanism of this protection
is incompletely described. Here we demonstrate that protection of cardiomyocytes by …

Endothelial-cardiomyocyte interactions in cardiac development and repair

PCH Hsieh, ME Davis, LK Lisowski… - Annu. Rev. Physiol …, 2006 - annualreviews.org
▪ Abstract Communication between endothelial cells and cardiomyocytes regulates not only
early cardiac development but also adult cardiomyocyte function, including the contractile …

Custom design of the cardiac microenvironment with biomaterials

ME Davis, PCH Hsieh, AJ Grodzinsky… - Circulation research, 2005 - Am Heart Assoc
Many strategies for repairing injured myocardium are under active investigation, with some
early encouraging results. These strategies include cell therapies, despite little evidence of …

Intraoperative neurophysiological monitoring during spine surgery: a review

…, D Jeyanandarajan, C Hansen, G Zada, PC Hsieh - Neurosurgical …, 2009 - thejns.org
Spinal surgery involves a wide spectrum of procedures during which the spinal cord, nerve
roots, and key blood vessels are frequently placed at risk for injury. Neuromonitoring …

Biodegradable core/shell fibers by coaxial electrospinning: processing, fiber characterization, and its application in sustained drug release

C Wang, KW Yan, YD Lin, PCH Hsieh - Macromolecules, 2010 - ACS Publications
Solutions of two biodegradable polymers, that is, poly(dl-lactic acid) (PDLLA) and poly(3-hydroxy
butyrate) (PHB), were individually delivered to the inner and outer channel of a coaxial-…