Objective To determine whether repeatedly overloading healthy cartilage disrupts mitochondrial
function in a manner similar to that associated with osteoarthritis (OA) pathogenesis. …

Metabolic adaptation of articular cartilage under joint loading is evident and matrix synthesis
seems to be critically tied to ATP. Chondrocytes utilize the glycolytic pathway for energy …

Background: This research was initiated to compare the long-term clinical safety and effectiveness
of the selectively constrained SECURE-C (Globus Medical, Audubon, Pennsylvania) …

Background The accuracy of quantitative real-time RT-PCR (qRT-PCR) is often influenced
by experimental artifacts, resulting in erroneous expression profiles of target genes. The …

Mechanical loading is essential for articular cartilage homeostasis and plays a central role in
the cartilage pathology, yet the mechanotransduction processes that underlie these effects …

We recently introduced a novel pluronic F127 and hyaluronic acid‐based hydrogel (HG)
designed to deliver a broad range of therapeutics. The reverse‐thermal responsive HG exhibits …

Study Design. This study investigated tissue integrity and viability of cells in an organ culture
system of intervertebral disc (IVD) with adjoining vertebral bodies. Objective. The goal of …

There is a need to develop mechanically active culture systems to better understand the role
of mechanical stresses in intervertebral disc (IVD) degeneration. Motion segment cultures …

Background Injuries to articular cartilage result in the development of lesions that form on
the surface of the cartilage. Such lesions are associated with articular cartilage degeneration …

Irregular bone remodeling is associated with a number of bone diseases such as osteoporosis
and multiple myeloma. Computational and mathematical modeling can aid in therapy and …