Background: The randomized controlled trial (RCT) is the gold standard study design allowing
critical comparison of clinical outcomes while minimizing bias. Traditionally clinical trials …

Purpose Randomized controlled trials (RCTs) are the gold standard for comparing clinical
interventions. Statistical significance as reported via a P value has been used to determine if a …

pH-responsive polymers have been synthesised by grafting l-valine (PV-75), l-leucine (PL-75)
and l-phenylalanine (PP-75) onto the pendant carboxylic acid moieties of a pseudo-…

Context: The rising popularity and intensity of youth sports has increased the incidence of
patellar dislocation. These sports-related injuries may be associated with significant morbidity …

Study Design. Retrospective database analysis. Objective. To identify preoperative risk
factors for emergency department (ED) visit and unplanned hospital readmission after primary …

Globally, the burden of musculoskeletal conditions continues to rise, disproportionately
affecting low and middle-income countries (LMICs). The ability to meet these orthopaedic …

Monitoring for drug-induced liver injury (DILI) via serial transaminase measurements in
patients on potentially hepatotoxic medications (eg, for HIV and tuberculosis) is routine in …

The use of small interfering RNAs (siRNAs) to down‐regulate the expression of disease‐associated
proteins carries significant promise for the treatment of a variety of clinical disorders. …

The clinical potential of short interfering RNA (siRNA) based therapeutics remains hindered
by the challenge of delivering enough siRNA into the cytoplasm to yield a clinically relevant …

Background Pediatric spinal fusion may be associated with significant intraoperative blood
loss, leading to complications from transfusion, hypoperfusion and coagulopathy. One …