<p id="p001">Six healthy young male volunteers at a contract research organization were
enrolled in the first phase 1 clinical trial of TGN1412, a novel superagonist anti-CD28 …

The projects that motivated initial development of many of the ideas in this book were
primarily large engineering projects in the energy sector: large-scale Arctic pipelines in the far …

Selling Places explores the fascinating development of the place marketing and promotion
over the last 150 years, drawing on examples from Northern America, Britain and continental …

This paper builds on discussions that took place over a series of meetings in the UK of the
Rethinking Project Management Network. The management of uncertainty is seen as a …

This paper argues that all current project risk management processes induce a restricted
focus on the management of project uncertainty. In part this is because the term ‘risk’ …

The book examines the way that place, defined as a geographical area with a specific identity
that sets it apart, has been marketed in the past and is currently being marketed. Spatially, …

Despite international efforts to ‘roll back malaria’ the 2008 World Malaria Report revealed
the disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …

OBJECTIVE: To develop evidence-based clinical practice guidelines for interventional
techniques in the diagnosis and treatment of chronic spinal pain. METHODOLOGY: Systematic …

Background Precision medicine approaches that target patients on the basis of disease
subtype have transformed treatment approaches to cancer, asthma, and other heterogeneous …

In recent years, nitric oxide (NO), a gas previously considered to be a potentially toxic
chemical, has been established as a diffusible universal messenger that mediates cell–cell …