OBJECTIVE There is a scarcity of large multicenter data on how preoperative lumbar symptom
duration relates to postoperative patient-reported outcomes (PROs). The objective of this …

The mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism,
and angiogenesis. While showing clinical efficacy in a subset of tumors, rapamycin and …

(CH3), CHNHSi (CH3) 3 (31.4) 1.2-0.1 31.3 see ref 5 effect. We also measured the pK of
2BP against 3BP and against benzhydryl phenyl thioether, again observing ex-cellent …

The PI3K/Akt signaling pathway is a key pathway in cell proliferation, growth, survival, protein
synthesis, and glucose metabolism. It has been recognized recently that inhibiting this …

The mammalian target of rapamycin (mTOR) is a major component of the phosphoinositide
3-kinase (PI3K)/AKT signaling pathway that is dysregulated in 50% of all human …

The development of HKI‐272 and EKB‐569 for the treatment of cancer is described. These
compounds function as irreversible inhibitors of some members of the ErbB family of receptor …

Kinases have emerged as ubiquitous but highly challenging targets for drug discovery. The
human genome has 518 kinases1 and many of these play critical roles in cell growth and …

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin
receptor pathways and thus an attractive therapeutic target for diabetes and obesity. Starting …

Mechanism based inhibitors of HCMV protease have been designed based on the
monocyclic β-lactam nucleus, which have been shown to acylate the viral enzyme in a time …

Previous studies have demonstrated the feasibility of implantation of human blood cells or
tissues in lethally irradiated mice or rats, radioprotected with SCID mouse bone marrow cells: …