To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with
somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two …

While mutations affecting protein-coding regions have been examined across many cancers,
structural variants at the genome-wide level are still poorly defined. Through integrative …

Breast cancers are comprised of molecularly distinct subtypes that may respond differently to
pathway-targeted therapies now under development. Collections of breast cancer cell lines …

Objective To assess the feasibility of minimally invasive spine surgery (MIS) techniques in
the correction of lumbar degenerative deformity.

Study Design. A description of a novel surgical approach to the lumbar spine and a prospective
evaluation of the early surgical outcomes. Objectives. Describe the early postoperative …

MATERIALS AND METHODS CLINICAL MATERIAL Twenty-nine patients were followed for
one month to 44 months with an average follow-up of 29, 3 months, There were 23 females …

Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology
research platform to study tumor evolution, mechanisms of drug response and resistance…

Background Metastatic castration resistant prostate cancer (mCRPC) is incurable and
progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus, there …

Motivation: A current challenge in understanding cancer processes is to pinpoint which
mutations influence the onset and progression of disease. Toward this goal, we describe a …

Vast amounts of molecular data are being collected on tumor samples, which provide
unique opportunities for discovering trends within and between cancer subtypes. Such cross-…