Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like
sepsis 1 . Microbial pathogen-associated molecular patterns (PAMPs) activate innate …

Trauma and sepsis can cause acute lung injury (ALI) and Acute Respiratory Distress Syndrome
(ARDS) in part by triggering neutrophil (PMN)-mediated increases in endothelial cell (EC…

Methods: Femur fracture reamings (FFx) from 10 patients were spun to remove bone particulates.
Supernatants were assayed for mitochondrial DNA. Mitochondria were isolated from …

Systemic inflammatory response syndrome (SIRS) is a fundamental host response common
to bacterial infection and sterile tissue injury. Systemic inflammatory response syndrome can …

Background and Purpose: Acute ischemic stroke (AIS) is a rare occurrence during pregnancy
and the postpartum period. Existing literature evaluating endovascular mechanical …

Medulloblastoma (MB) is the most common malignant pediatric posterior fossa tumor. Recent
genetic, epigenetic, and transcriptomic analyses have classified MB into three subgroups, …

Mechanistic target of rapamycin (mTOR), which functions via two multiprotein complexes
termed mTORC1 and mTORC2, is positioned in the canonical phosphoinositide 3‑kinase‑…

Glioblastoma (GB) is a highly aggressive and infiltrative brain tumor characterized by poor
outcomes and a high rate of recurrence despite maximal safe resection, chemotherapy, and …

Bacterial DNA (bDNA) contains hypomethylated “CpG” repeats that can be recognized by
Toll-like receptor 9 (TLR-9) as a pathogen-associated molecular pattern. The ability of bDNA …

Traumatic spinal cord injury (SCI) is untreatable and remains the leading cause of disability.
Neuroprotection and recovery after SCI can be partially achieved by rapamycin (RAPA) …