Stem cells and intervertebral disc regeneration overview—what they can and can't do

G Vadalà, L Ambrosio, F Russo, R Papalia… - International Journal of …, 2021 - ijssurgery.com
Background: Low back pain (LPB) is the main cause of disability worldwide with enormous
socioeconomic burdens. A major cause of LBP is intervertebral disc degeneration (IDD): a …

[HTML][HTML] Application of stem cells in the repair of intervertebral disc degeneration

W Zhang, T Sun, Y Li, M Yang, Y Zhao, J Liu… - Stem cell research & …, 2022 - Springer
Intervertebral disc degeneration (IDD) is a common disease that increases with age, and its
occurrence is stressful both psychologically and financially. Stem cell therapy for IDD is …

Cell therapy for treatment of intervertebral disc degeneration: a systematic review

HJ Meisel, N Agarwal, PC Hsieh, A Skelly… - Global spine …, 2019 - journals.sagepub.com
Study Design: Systematic review. Objective: To review, critically appraise, and synthesize
evidence on use of cell therapy for intervertebral disc repair. Methods: A systematic search …

Stem cell approaches to intervertebral disc regeneration: obstacles from the disc microenvironment

F Wang, R Shi, F Cai, YT Wang… - Stem Cells and …, 2015 - liebertpub.com
Intervertebral disc (IVD) degeneration results in segmental instability and irritates neural
compressive symptoms, such as low back pain and motor deficiency. The transplanting of …

[HTML][HTML] A review: Methodologies to promote the differentiation of mesenchymal stem cells for the regeneration of intervertebral disc cells following intervertebral disc …

T Ohnishi, K Homan, A Fukushima, D Ukeba, N Iwasaki… - Cells, 2023 - mdpi.com
Intervertebral disc (IVD) degeneration (IDD), a highly prevalent pathological condition
worldwide, is widely associated with back pain. Treatments available compensate for the …

[HTML][HTML] Concerns about cell therapy for intervertebral disc degeneration

B Peng, Y Li - NPJ Regenerative medicine, 2022 - nature.com
Low back pain is a very common symptom in people all over the world, which is now the
leading cause of disability worldwide 1, 2. Although the specific cause of low back pain is …

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

D Sakai, GBJ Andersson - Nature Reviews Rheumatology, 2015 - nature.com
Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain,
which accounts for disability worldwide. Despite the known outcomes of the IVD …

[HTML][HTML] Clinical development of regenerative medicine targeted for intervertebral disc disease

D Sakai, J Schol, M Watanabe - Medicina, 2022 - mdpi.com
Low back pain is critical health, social, and economic issue in modern societies. This
disease is often associated with intervertebral disc degeneration; however, contemporary …

Stem cell regeneration of degenerated intervertebral discs: current status

SM Richardson, JA Hoyland - Current pain and headache reports, 2008 - Springer
Low back pain (LBP) is one of the most common musculoskeletal conditions, and
intervertebral disc (IVD) degeneration is associated with most cases. Although many …

[HTML][HTML] Cell therapy for intervertebral disc repair: clinical perspective

D Sakai, J Schol - Journal of orthopaedic translation, 2017 - Elsevier
Low back pain is the main cause of disability and is associated with intervertebral disc
degeneration. Contemporary treatments are limited to palliative therapeutics or aggressive …