Abstract
Background Low back pain (LBP) is 1 of the most common problems that present in 80% of people. LBP can be caused by some pathologies, with discogenic pain being 1 source. Pain from LBP can become chronic and also cause disability. Treatment options for LBP varied from conservative to operative, and a novel treatment nowadays is using stem cells therapy to treat with pain from LBP.
Methods Database searches from Pubmed and ScienceDirect from inception to 13 September 2023. A total of 283 discogenic LBP cases from 8 articles. This study measured clinical outcomes using a visual analog scale (VAS) and Oswestry Disability Index (ODI) obtained from each study.
Results Functional outcomes in patients treated with stem cell therapy showed significant improvement ODI and VAS (P < 0.00001). Improvement also showed in Pfirrmann grade before and after treatment with stem cells (P = 0.005). Subgroup analyses using bone marrow aspirate concentrate also showed significant differences in both ODI and VAS (P < 0.00001).
Conclusion Stem cells therapy could be beneficial as an option of treatment for discogenic LBP in improving pain and activity of daily living.
Clinical Relevance Intradiscal stem cell therapy is a promising alternative for managing discogenic low back pain, offering improvements in pain and function.
Level of Evidence 4.
Footnotes
Funding The authors received no financial support for the research, authorship, and/or publication of this article.
Declaration of Conflicting Interests The authors report no conflicts of interest in this work.
- This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2025 ISASS. To see more or order reprints or permissions, see http://ijssurgery.com.
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