Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma.

AK Metzger, VC Sheffield, G Duyk… - Proceedings of the …, 1991 - National Acad Sciences
We detected a germ-line mutation of the p53 gene in a patient with a malignant ependymoma
of the posterior fossa. This mutation, which was found at codon 242, resulted in an amino …

Deletion mapping of the medulloblastoma locus on chromosome 17p

PH Cogen, L Daneshvar, AK Metzger, MSB Edwards - Genomics, 1990 - Elsevier
Isochromosome 17q has previously been observed consistently in cytogenetic studies of
medulloblastoma, the most common posterior fossa neoplasm in children. We performed a …

Cervicomedullary junction compression caused by vertebral artery dolichoectasia and requiring surgical treatment: case report

EE Ubogu, CM Chase, MA Verrees, AK Metzger… - Journal of …, 2002 - thejns.org
✓ A case of progressive brainstem syndrome secondary to vertebral artery (VA) dolichoectasia
is reported. The patient presented with partial bilateral abduction paralysis, which …

Intraoperative MRI with a Rotating, Tiltable Surgical Table: A Time–Use Study and Clinical Results in 122 Patients

…, SG Nour, ML Meyers, AK Metzger… - American Journal of …, 2007 - Am Roentgen Ray Soc
OBJECTIVE. The objective of our study was to evaluate intraoperative low-field MRI for the
frequency and duration of imaging sessions needed during surgery, the direct additional …

Multiple genetic aberrations including evidence of chromosome 11q13 rearrangement detected in pituitary adenomas by comparative genomic hybridization

AK Metzger, G Mohapatra, YA Minn, AW Bollen… - Journal of …, 1999 - thejns.org
Object. This study was conducted to determine whether comparative genomic hybridization (CGH)
is a more sensitive method for detecting genetic aberrations than other tests currently …

A denaturing gradient gel electrophoresis assay for sensitive detection of p53 mutations

JS Beck, AE Kwitek, PH Cogen, AK Metzger, GM Duyk… - Human genetics, 1993 - Springer
p53 is a tumor suppressor gene located on 17p, a region of the human genome frequently
deleted in tumors. Mutation of the p53 gene is an important step leading to development of …

Loss of heterozygosity for chromosome 22 DNA sequences in human meningioma

…, L Daneshvar, AM Bowcock, AK Metzger… - Cancer genetics and …, 1991 - Elsevier
Monosomy of chromosome 22 in meningioma was the first consistent cytogenetic anomaly
reported for a solid tumor. Although most meningiomas are isolated sporadic lesions, multiple …

Utilization of Bone-Anchored Annular Defect Closure to Prevent Reherniation Following Lumbar Discectomy: Overcoming Barriers to Clinical Adoption and Market …

…, WC Watters, BH Grunch, AK Metzger… - International Journal of …, 2024 - ijssurgery.com
While achieving premarket approval from the US Food and Drug Administration represents
a significant milestone in the development and commercialization of a Class III medical …

Intraoperative MR systems. Low-field approaches.

JS Lewin, AK Metzger - Neuroimaging Clinics of North America, 2001 - europepmc.org
Numerous different concepts in low-and mid-field intervention have been described and
applied for percutaneous intervention and intraoperative MR imaging, and each has …

Optimizing brain tumor resection. Low-field interventional MR imaging.

AK Metzger, JS Lewin - Neuroimaging Clinics of North America, 2001 - europepmc.org
In this article, the authors describe their strategy for intraoperative MR image guidance of tumor
resection at low-field (0.2 T) strength. It is their opinion that intraoperative imaging is most …