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Research ArticleOther & Special Categories

Safety and Efficacy of Balloon Kyphoplasty for Vertebral Fractures With Posterior Wall Disruption

Jennifer L. Perez, Alp Ozpinar, Nitin Agarwal, Emily Hacker, NIMA Alan and Peter C. Gerszten
International Journal of Spine Surgery April 2021, 15 (2) 353-358; DOI: https://doi.org/10.14444/8046
Jennifer L. Perez
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
PHD
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Alp Ozpinar
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
MD
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Nitin Agarwal
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
MD
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Emily Hacker
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
BS
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NIMA Alan
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
MD
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Peter C. Gerszten
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
MD, MPH
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ABSTRACT

Background: Percutaneous balloon kyphoplasty (BK) is widely accepted as both a safe and effective method for the treatment of symptomatic benign vertebral compression fractures (VCFs) of the thoracic and lumbar spines. A disruption in the posterior wall of the affected vertebra is often considered to be a relative or an absolute contraindication to BK. This study was performed to determine the safety as well as the efficacy of BK for vertebral body compression fractures associated with posterior wall disruption.

Methods: This was a retrospective, nonrandomized clinical cohort investigation of patients with VCF and posterior wall disruption treated with BK between 2010 and 2018. All cases were performed using a bipedicular technique. Each case was examined for cement leakage, anterior vertebral body height restoration, improvement in pain (determined by VAS) from baseline and 6-week postprocedure, and clinical sequelae from cement leakage.

Results: Ninety-eight consecutive patients with 157 VCF levels who underwent BK were evaluated. There was a significant improvement in anterior vertebral height, vertebral wedge angle, and local kyphotic angle in all cases. The mean preoperative VAS improved from 8.7 preprocedure to 2.5 postprocedure (P = .001). There were 14 (9%) cases with asymptomatic cement leakage outside of the vertebral body, and no patients experienced postprocedure neurological symptoms at the 6-week follow up.

Conclusions: BK in the setting of posterior wall disruption was found to be a safe and highly effective treatment for patients with benign compression fractures. Posterior wall disruption should not be considered an absolute contraindication to BK.

  • cement augmentation
  • osteoporosis
  • spine fracture
  • vertebral compression fracture
  • vertebroplasty

INTRODUCTION

Vertebral compression fractures (VCFs) pose a significant health problem, affecting an estimated 700 000 patients in the United States each year. Approximately 85% of VCFs are caused by primary osteoporosis, while the remainder are due to secondary osteoporosis or malignancies.1 Regardless of the etiology, loss of height from VCFs leads to progressive sagittal spinal deformity and kyphosis of the thoracic and lumbar spine, resulting in many morbidities including chronic pain, spinal stenosis and deformity, decreased lung capacity, and an overall decreased quality of life.2

Traditional treatments for VCFs included conservative nonsurgical medical treatments (NSTs) such as physical therapy, bed rest, various analgesic agents, and back braces to reduce symptoms.3 However, NSTs fail to restore spinal alignment and can increase the rate of demineralization, thereby causing persistent, intractable pain or neurological deterioration that requires invasive interventions in some patients.2,4

Percutaneous vertebroplasty (PVP) and percutaneous balloon kyphoplasty (BK) are widely used transpedicular cement augmentation procedures used in the surgical management of VCFs. PVP involves forced injection of low viscosity polymethylmethacrylate (PMMA) cement into the closed space of the collapsed vertebral body.5 While PVP has been shown to have significant benefit over NSTs,6,7 authors of other studies have questioned these results.8,9 The PVP procedure fails to restore vertebral body height and correct spinal deformities and is associated with cement leakage rates as high as 65% in VCFs from metastases and 30% osteoporotic VCFs.10,11

BK is a procedure that reduces pain and, in some cases, may correct kyphosis secondary to collapsed vertebral bodies.11,12 BK involves insertion of an inflatable bone tamp into the fractured vertebral body for endplate elevation followed by fixation of the fracture with bone cement. This allows cement augmentation to be performed under a more controlled, low-pressure environment that reduces the risk of cement extravasation. This technique therefore has the advantage of vertebral body height restoration and possible decreased complications resulting from cement leakage.13,14 However, posterior vertebral body wall (PVBW) involvement is considered by many clinicians a relative or absolute contraindication for BK.15,16

This study was performed to evaluate the safety and efficacy of BK for benign VCFs associated with posterior wall disruption. If BK were shown to be safe as well as effective in patients with PVBW defects, it may potentially alleviate the need for more invasive procedures and the associated complications in this patient population.

MATERIALS AND METHODS

Patient Selection

From January 2010 to January 2018, 98 consecutive patients (157 VCF levels) who underwent a BK procedure in our hospital for unrelieved back pain from osteoporotic fractures and/or minor trauma leading to compression fractures (Figure 1) were included in this study. All patients were aged 65 years and older and had fractures in the thoracic or lumbar vertebrae with preoperative computed tomography (CT)-confirmed posterior wall disruption and demonstrated evidence of vertebral body edema based upon magnetic resonance imaging (MRI; acute or subacute fractures). Patients with metastatic spinal fractures, neurological deficits, and patients who had not undergone appropriate conservative, nonsurgical treatment were excluded from the study.

Figure 1
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Figure 1

Preoperative computed tomography scan demonstrating 2 column fractures with posterior wall defect. (A) Axial view of L1 vertebra. (B) Sagittal view of lumbar spine with vertebral body height.

Surgical Procedure

All patients underwent general anesthesia in the prone position. A single C-arm was used for fluoroscopic guidance. Bipedicular access was obtained percutaneously in all cases (Figure 2). The Kyphon Express II (Medtronic Spinal and Biologics, Memphis, Tennessee) kit was used for all procedures. Balloons were inserted into the central anterior two-thirds of the vertebral body. Balloons were dilated appropriately and terminated when the balloon approached the subchondral plate (Figure 3). After balloon removal, high-viscosity barium-opacified PMMA cement was infused (Figure 4; Kyphon Xpede bone cement, Medtronic Spine LLC, Sunnyvale, California). To ensure there is no cement leakage, the cement is made particularly thick before injections, and a series of intraoperative images are taken to make sure no cement leakage is present in the posterior one-third of vertebral body.

Figure 2
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Figure 2

Intraoperative fluoroscopic image demonstrating bipedicular approach.

Figure 3
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Figure 3

Sequential balloon dilation in bipedicular fashion. (A) Lateral and (B) Anterior-Posterior fluoroscopic views showing good endplate reduction and improvement of anterior vertebral height intraoperatively.

Figure 4
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Figure 4

Fluoroscopic image demonstrating cement filling at the conclusion of the case prior to trocar removal. (A) Lateral and (B) Anterior-Posterior views showing cement filling with no leakage.

Outcomes

Functional outcomes were assessed preoperatively and at 6 weeks. Pain (average back pain in the past week) was assessed subjectively using a visual analog score (VAS) from 0 (no pain) to 10 (worst pain imaginable).

Standing anteroposterior and lateral spine radiographs were obtained preoperatively and intraoperatively before conclusion of the procedure. Anterior vertebral body height (AVBH), local kyphotic angle, and vertebral wedge angle (VWA) were calculated preoperatively and intraoperatively. Local kyphotic angle was defined as the angle formed by lines drawn at a 90° to the lines parallel to the most caudal and cranial fractured vertebral body endplates. All measurements were made directly on scan using the institutional electronic image viewer.

Cement leakage was assessed via intraoperative fluoroscopic images. Complications, including mortality and neurological deficits, were assessed at 6 weeks postoperatively.

Statistical Analysis

Statistical analysis was performed using IMB SPSS Statistics (SPSS Inc., Chicago, Illinois). Descriptive statistics were generated using independent sample t tests for continuous variables. Statistical significance was accepted at a P value of <.05.

RESULTS

Patient demographics are outlined in Table 1. Ninety-eight consecutive patients (52 [53%] female; 46 [47%] male) with 157 levels of BK were identified to fit the inclusion criteria. Mean body mass index (BMI) was 28.2 (±8.3). Ninety-four levels were in the thoracic spine, and 63 were in the lumbar spine. Patients were divided into 2 groups: Group 1 included those who underwent BK at levels T2–L2 (121 levels), and group 2 included those who underwent BK at levels L3–L5 (36 levels); this categorization is consistent with that performed in previous studies.17,18 The upper lumbar vertebrae (L1, L2) were grouped with the thoracic vertebrae, given their similarity in alignment with the thoracic spine.

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Table 1

Patient demographics and characteristics.

The results of this study are summarized in Table 2. In group 1, the mean AVBH was 16.4 (±4.4) mm preprocedure and 21.3 (±5.3) mm postprocedure (P = .001). Mean VWA improved from 9.8 (±4.9) to 4.7 (±3.1). Mean preoperative kyphotic angle improved from 13.3 (±10.6) to 8.8 (±10.9). In group 2, the mean AVBH was 24.6 (±5.4) mm preprocedure and 26.5 (±4.3) mm postprocedure (P = .001; Figure 5). Mean VWA improved from 3.6 (±4.7) to 1.1 (±5.4). Mean preoperative kyphotic angle improved from −11.5 (±18.4) to −14.4 (±16.5).

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Table 2

Summary of radiographic results. Measurements in millimeters.

Figure 5
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Figure 5

Sagittal computed tomography scan demonstrating maintenance of improvement in lumbar spine vertebral body height from (A) preoperative to (B) 2 years postoperatively.

Overall, in both groups 1 and 2, the mean VAS improved from 8.7 preprocedure to 2.5 postprocedure (P = .001). Finally, there were 14 (9%) cases with asymptomatic cement leakage outside of the vertebral body. No patients developed new neurological symptoms after BK.

DISCUSSION

BK has become a frequently performed, minimally invasive spinal surgical procedure and is considered a safe and effective treatment for benign osteoporotic or traumatic VCFs. However, PVBW defects are considered a relative or absolute contraindication for BK15,16,19 due to the threat that balloon inflation may force fragments into the spinal canal, or posterior cement leakage may occur during PMMA insertion. This study demonstrated that BK in the setting of PVBW defects was associated with improvement in pain, increased postoperative vertebral body height, and correction of kyphosis. Furthermore, no patient developed new neurological symptoms after surgery because of cement leakage.

Osteoporotic or trauma-induced compressions fractures commonly result in spinal deformity such as kyphosis, resulting from increased sagittal plane deformity, which causes biomechanical stress on the spine. This kyphosis can cause intractable pain, spinal canal stenosis, and neurological symptoms that may require surgical intervention. Further, it has been suggested that PVBW defects may result in greater postoperative progression of vertebral collapse than those with endplate or anterior wall damage alone.20,21 However, BK has been recommended as the most appropriate treatment of VCFs in the majority of clinical scenarios.22,23 Indeed, in a prospective study of patients with VCF, Maestretti et al18 found no loss of correction of the vertebral and segmental kyphosis angle at 10 years postprocedure. Furthermore, Abdelgawaad et al17 reported an improvement in both the vertebral angle and vertebral body height in patients with VCF complicated by PVBW defect. In agreement with these results, we found no loss of corrected vertebral height or loss of the corrected kyphotic angles at the 6-week follow up compared with the immediate postoperative period.

Cement leakage is considered one of the most common serious complications of BK, and the risk is thought to be higher in the presence of a PVBW defect. This could be a result of the anterior and posterior longitudinal ligaments acting as a physical barrier to limiting or preventing cement leakage during balloon inflation. However, in 1 study using human cadaveric burst fracture models, traumatic ligamentous and bony damage did not significantly increase the frequency or amount of cement leakage.24 Further, Abdelgawaad et al17 found a 22.5% asymptomatic leakage (cortical, diskal, or vascular) rate in a prospective study of 82 patients with traumatic VCF and PVBW defects. Importantly, they found no leakage of cement into the spinal canal in any case.17

In addition, intraoperative cement extravasation may cause serious neurological injury or pulmonary cement embolism. While only a few case reports have documented neurological injuries, the incidence of pulmonary cement embolism is estimated to be between 3% and 23%, though the majority had no clinical significanc.25,26 In the current study, no patients experienced intraoperative pulmonary cement embolism. Rarely, postoperative symptomatic cement leakage may occur and have serious neurologic complications such as worsening pain, radiculopathy, spinal cord compression, or cauda equina compression.27,28 In the current study, 14 (9%) of patients experienced postoperative cement leakage. However, all cases of cement leakage were asymptomatic, and no patients experienced pulmonary cement embolism or any new neurological deficits. These findings are consistent with Abdelgawaad et al,17 who also found no pulmonary cement embolism or neurologic complications after cement leakage in patients with traumatic VCF complicated by PVBW defects. Future studies may use advanced imaging modalities to address the inherent limitations of using fluoroscopy to detect cement leakage and cement embolism.

CONCLUSIONS

This study supports the safety and efficacy of BK for the management of benign VCFs in the setting of a PVBW defect. Although posterior wall defects were previously considered a relative or absolute contraindication to BK in patients with benign vertebral wall compression fractures, carefully selected patients29 can still achieve a high level of clinical success and safety using BK in this relatively common clinical setting.

Footnotes

  • Disclosures and COI: Data from this study was presented at the 35th Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Spine Summit, Miami, FL, March 14–17, 2019. The authors received no funding for this study and report no conflicts of interest.

  • This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2021 ISASS

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Safety and Efficacy of Balloon Kyphoplasty for Vertebral Fractures With Posterior Wall Disruption
Jennifer L. Perez, Alp Ozpinar, Nitin Agarwal, Emily Hacker, NIMA Alan, Peter C. Gerszten
International Journal of Spine Surgery Apr 2021, 15 (2) 353-358; DOI: 10.14444/8046

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Safety and Efficacy of Balloon Kyphoplasty for Vertebral Fractures With Posterior Wall Disruption
Jennifer L. Perez, Alp Ozpinar, Nitin Agarwal, Emily Hacker, NIMA Alan, Peter C. Gerszten
International Journal of Spine Surgery Apr 2021, 15 (2) 353-358; DOI: 10.14444/8046
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