Abstract
Background The unilateral biportal endoscopic (UBE) technique provides minimally invasive decompression for degenerative lumbar canal stenosis (DLCS). With appropriate control of the hydrostatic pressure of normal saline irrigation, the surgery can be performed in a clear and magnified surgical field through 2 small surgical wounds.
Methods A review of published literature in PubMed was performed to identify studies of UBE decompression for DLCS. The outcome measures include operation time, length of hospital stay, estimated blood loss, visual analog scale (VAS) scores for back and leg pain, Oswestry Disability Index (ODI), and the Macnab criteria.
Results A total of 76 relevant studies were retrieved through the PubMed search. After screening, 15 studies comprising 6 case series, 6 comparative studies, and 3 randomized controlled trials were included in this review. Significant improvements in pain and neurological symptoms were obtained in all studies. In the 6 case series studies, the outcome measures were extracted from each study and summarized. The follow-up periods ranged from 8.6 to 29 months. The operation time was 72.0 min. The VAS score for leg pain was reduced from 7.8 to 1.7, and the VAS score for back pain was reduced from 5.8 to 1.7. The ODI was reduced from 63.0 to 20.7, and 87.3% of patients reported good to excellent outcomes according to the Macnab criteria. The complication rates ranged from 5.5% to 13.8%, with dural tear having the highest incidence rate. In the comparative studies and randomized controlled trials examining the UBE, microscopic, microendoscopic, and uniportal endoscopic techniques, the UBE technique showed treatment results that were comparable with the others. Compared with the microscopic technique, the UBE technique resulted in significantly less tissue trauma and quicker recovery with less wound pain, lower serum creatine kinase and C-reactive protein levels, and lower ODI in the very early postoperative period. The UBE technique also provided adequate decompression with less facet joint destruction than all the other decompression techniques.
Conclusions The UBE technique is safe and effective for decompression of DLCS. Along with its efficacy in decompression, this technique is capable of preserving segmental stability. However, a long-term comparative study is required to verify this hypothesis.
INTRODUCTION
Degenerative lumbar canal stenosis (DLCS) is the most common indication for spinal surgery in the elderly population.1 Wide laminectomy with or without concomitant fusion was the standard surgical procedure for decades.2–4 This classical approach required a sizable surgical wound and an extensive soft tissue dissection, which could lead to fatty degeneration, atrophy, and weakness of the paraspinal muscles.5,6 The randomized controlled trials showed that fusion added little value to decompression for DLCS.7,8 Therefore, the optimal treatment for DLCS could be the balance between adequate decompression and preservation of segmental stability.
In 1983, Kambin and Gellman first proposed the concept of percutaneous lateral discectomy to minimize the soft tissue damage caused by surgical exposure.9 This concept helped inspire the development of minimally invasive spine surgery. Various minimally invasive techniques were developed to overcome the limitations of small surgical wounds and to provide effective decompression of the neural tissues. Some of the benefits to patients of these techniques were small surgical wounds, less soft tissue damage, less postoperative pain, faster recovery, and the potential for better long-term results as compared to the open techniques.10
Unilateral biportal endoscopic (UBE) decompression is a percutaneous endoscopic technique not confined by the working tube or the working channel. It is performed through 2 small separated surgical wounds on the right or left side of the spinous process. One portal is used for the endoscope and saline inflow, and the other is used for instrument passage and saline outflow. Unilateral laminotomy is followed by bilateral decompression under the endoscope. Through continuous normal saline irrigation and a high-definition endoscope, the surgeon can perform very precise decompression in a clear and magnified endoscopic surgical field. This novel technique has attracted a lot of attention from spine surgeons who are interested in minimally invasive spine surgery.
In this study, we reviewed the literature and summarized the clinical outcomes of UBE decompression for DLCS.
METHODS
Literature Search and Screening
A PubMed search of English literature was conducted using the terms “biportal endoscopic spinal surgery” and “lumbar spine.” We conducted a thorough review of the literature and manually checked the reference lists. We included only studies of lumbar canal decompression. Studies of lumbar disc herniation, foraminal stenosis, and cervical and thoracic disorders; studies with mixed diagnoses; and studies combined with fusion were excluded. Studies without functional outcome evaluation were also excluded. Studies from the same institution were carefully reviewed to avoid any possible overlap in data collection. Only the studies that provided the most comprehensive data were included
Data Extraction
Data were extracted for information including first author name, publication year, study type, number of patients, and follow-up period. The collected outcome measures were operative time, length of hospital stay, estimated blood loss, visual analog scale (VAS) scores for back pain and leg pain, Oswestry Disability Index (ODI), outcomes according to the Macnab criteria, and complications. All data were summarized for analysis.
RESULTS
Study Selection
A total of 76 potentially relevant studies were retrieved through the PubMed search. After the first screening of titles and abstracts, 31 studies were excluded. The second screening was a detailed full-text investigation of the remaining 45 studies. Following the second screening, another 31 studies were excluded: 10 technical notes, 9 with mixed diagnoses, 6 for complication management, 3 case reports, 1 with only a study protocol proposal, 1 with only a learning curve analysis, and 1 in which no tool was used for the outcome evaluation. Therefore, 14 studies fulfilled the inclusion criteria.11–24 Of the 14 studies, 2 studies conducted by the same authors using the same patient population were published sequentially as a preliminary report and a formal report. Only the formal report was included.14 In addition, 2 studies25,26 were found from a manual check of the reference lists of the 45 studies that met the inclusion criteria. A total of 15 studies comprising 6 case series, 6 comparative studies, and 3 randomized controlled trials were included in this review (Figure S1).
Case Series
The 6 case series studies included 386 patients with an average age of 62.2.15,20,22,24–26 The results are summarized in Table 1. The overall weighted operation time was 72.0 min. The intraoperative blood loss was reported in only 1 study because the amount was minimal and diluted by the continuous irrigation of normal saline. The average hospital stay was reported in only 2 studies. The follow-up periods ranged from 8.6 to 29 months. The VAS score for leg pain was reduced from 7.8 to 1.7 in 5 studies. The VAS score for back pain was reduced from 5.8 to 1.7 in only 3 of the 6 studies. The ODI was reduced from 63.0 to 20.7 in 5 of the 6 studies. All studies reported that improvement was significant and sustained at the final follow-up. Moreover, 87.3% of patients reported good to excellent results according to the Macnab criteria.
Summary of case series studies.
There were a total of 32 complications reported in these 6 studies with complication rates ranging from 5.5% to 13.8%. The dural tear (16 cases) was the most frequently encountered complication, followed by transient neurological symptoms (5 cases), incomplete decompression (5 cases), epidural hematoma (3 cases), and postoperative headache (3 cases). One dural tear was recognized during the operation and was repaired directly using endoscopic techniques. All the other dural tears were treated conservatively with no neurological sequels. Reoperation was required for 5 patients due to incomplete decompression, recurrence of neurological symptoms, and epidural hematoma.
Comparative Studies
A total of 6 comparative studies were identified and included in this review (Table 2).
Summary of comparative studies.
Two retrospective studies and 1 prospective study compared the clinical results between the microscopic (MS) technique and the UBE technique.13,16,23 Each study group was small (30–54 patients). Two studies had only short-term follow-up (12 and 14.5 months), and 1 study had midterm follow-up (more than 2 years). Faster recovery was observed with the UBE technique as well as a significantly lower VAS score, ODI, serum creatine kinase level, and serum C-reactive protein (CRP) level during the very early postoperative period.13 However, at final follow-up, clinical results including operation time, improvement in VAS for leg and back pain, and ODI showed no significant difference between these 2 techniques. Significantly earlier ambulation and shorter hospital stay were noted in the UBE group.16 Complications, including dural tear and epidural hematoma, were similar between groups. Among the 237 patients in these 3 studies, there was only 1 surgical site infection in the MS group.13 Reoperations due to epidural hematoma were required for 2 patients, 1 in the MS group and 1 in the UBE group.16
Choi and Kim conducted a retrospective comparative study comparing UBE decompression, MS decompression, and spine fusion.21 The VAS scores for back and leg pain were greatly reduced in each group with no significant differences between groups. The need for blood transfusion was significantly less in the UBE group (0%) than in the MS group (33.3%) and the fusion group (85.4%). The serum CRP level was also significantly lower in the UBE group than in the MS and fusion groups. The complication rates were similar between the groups, but wound infections were noted only in the fusion group.
Heo et al conducted a retrospective study comparing the MS, UBE, and uniportal endoscopic (UE) techniques.18 The VAS score for back pain was significantly higher in the MS group on the first postoperative day. However, the VAS scores for back and leg pain and ODI at final follow-up showed no significant difference between groups.
Ito et al conducted a retrospective comparative study comparing microendoscopic (MED) and UBE techniques.11 The laminotomy area evaluated by 3-dimensional computed tomography was significantly smaller in the UBE group, with a higher facet joint preservation rate on both the ipsilateral and contralateral sides. The VAS scores for back and leg pain, ODI, and the results of EuroQol’s EQ-5D questionnaire were significantly improved in both groups. with no significant differences between them. Complications occurred more frequently in the MED group, but the difference was insignificant.
Randomized Controlled Trial
Two randomized controlled trials compared short-term treatment results between MS and UBE techniques.14,17 The UBE technique resulted in significantly shorter operation time, less drainage, less opioid use, and shorter hospital stays. However, the clinical outcomes showed no significant difference between groups in terms of VAS score and ODI at final follow-up.
Another randomized controlled trial examined the treatment results between MED and UBE techniques periodically for 2 years.12 The UBE techniques exhibited significantly shorter operation time, less estimated blood loss, and shorter hospital stays. The UBE technique was significantly superior in ODI and Zurich Claudication Questionnaire results for all periods. At the end of the second year, a significantly higher percentage of excellent results was noted in the UBE group (63% vs. 29%) according to the modified Macnab criteria.
Effectiveness of Decompression
Unilateral laminotomy for bilateral decompression is a well-established decompression technique that was used routinely in all the studies included in this review. The efficacy of decompression was usually evaluated by comparing the preoperative and postoperative cross-sectional dural area using magnetic resonance imaging. Significant dural expansion of up to 200% could be achieved using the UBE technique.15 The decompression effect of the UBE technique was significantly better than that of the UE technique and comparable to that of the MS technique, although clinical outcomes were similar among these 3 techniques.18,23
Preservation of Segmental Stability
Preservation of the facet joint was reported in 1 case series study and 1 comparative study. When the decompression is done using unilateral laminotomy for bilateral decompression, there is usually more facet joint destruction on the approach side than the contralateral side. With the UBE technique, the percentage of facet joint preservation was 84.2% on the approach side and 92.9% on the contralateral side.15 Compared with the MED technique, the facet preservation rate was similar on the approach side, but the UBE technique had a significantly higher preservation rate for the contralateral facet joints.11
Postdecompression segmental instability was studied in 2 comparative studies. There was no significant change in slippage or dynamic percentage of slip at the final follow-up in the UBE groups in both studies. However, when compared with the MS technique, the difference in the dynamic percentage of slip was insignificant in 1 study16 and significant in the other.13
Discussion
UBE decompression has been used as a minimally invasive surgical technique to treat lumbar disc herniation and spinal canal stenosis for more than 10 years.24,25,27,28 With recent advancements in endoscopic technology and surgical instruments, UBE techniques have been successfully applied to treat various disorders in the cervical, thoracic, and lumbar spines.29–31
For DLCS, adequate decompression can be achieved with the UBE technique. Up to 200% increments in the cross-sectional dura area after operation have been reported.15 The efficacy of decompression was found to be better than that of UE techniques and comparable with MS decompression.18 The UBE technique has several advantages over other minimally invasive surgical techniques. First, surgeons can handle the surgical instruments almost the same way as in open surgeries, without restriction from a rigid working channel or a tubular retractor.32 Second, the diameter of the endoscope used in UBE techniques is only 4 mm. The surgeon can advance the scope very close to the lesion, even into the contralateral lateral recess or intervertebral foramen. The closer the surgeon can get to the lesion, the smaller the laminotomy window that is needed for an adequate decompression. The study by Ito et al proved that the same decompression effect was achieved using UBE and MED techniques, while a smaller laminotomy was required for the UBE technique.11 Heo et al also reported a smaller facetectomy angle in the UBE technique compared with the UE technique.18
To avoid postdecompression segmental instability, the integrity of facet joints must be preserved as much as possible when pursuing a complete neural decompression. A biomechanical study demonstrated that facet joint destruction greater than 50% could lead to segmental instability.33 With the UBE technique, more than 80% of the facet joint on the approach side and more than 90% of the facet joint on the contralateral side could be preserved.15 These preservation rates are higher than those seen with the MED technique, especially on the contralateral side.11 There was no evidence of postdecompression segmental instability found after UBE decompression for DLCS.13,16 Therefore, these findings support the idea that decompression alone is enough, and fusion surgeries may be avoided to preserve the mobility of the lumbar spine.
One of the most important benefits of minimally invasive spine surgery is faster recovery due to minimal injury to the soft tissue and paraspinal muscles. When compared with the standard MS technique, the UBE technique caused less tissue trauma, which was reflected by lower serum creatine kinase and CRP levels in the very early postoperative period. However, the difference was not significant after 1 month. The UBE technique also resulted in significantly less postoperative pain, which led to early ambulation and shorter hospitalization.13,16
The most frequently encountered complication in UBE decompression was dural tear, with an incidence that varied from 1.5% to 9.7%.34–37 While most of the dural tears were very small and could be managed conservatively, a dural tear larger than 10 mm would need to be repaired to prevent cerebrospinal fluid leakage and its sequels.35 Direct dural repair under endoscope is possible but technically demanding. Therefore, a variety of alternative methods have been proposed to help effectively seal the dural tears.35–37 Like the UE technique, the UBE technique depends on continuous normal saline irrigation during the surgical procedure. The hydrostatic pressure may propagate upward through the dural tear and damage the central nervous system.38,39 Under circumstances without a dural tear, Choi et al suggested interrupting endoscopic procedures lasting longer than 30 min to avoid increasing intracranial pressure.38 Therefore, if the dural tear cannot be sealed effectively during the surgery or the surgeon is not confident about completing the surgical procedure effectively in a short period, the endoscopic surgery should be abandoned or converted to open surgery.
Epidural hematoma is not uncommon after UBE decompression for DLCS. Bleeding control in UBE techniques is very effective by using the hydrostatic pressure of the normal saline, radiofrequency wands, and bone wax. Sometimes surgeons misinterpret perfect hemostasis and assume no bleeding will continue after the surgical procedure. However, the bleeding does continue in the small dead space when the hydrostatic pressure stops. Although most epidural hematomas are asymptomatic, they may lead to inferior treatment results. Revision surgery might be necessary if canal encroachment is more than 50% with concomitant symptoms.40
All minimally invasive surgical techniques are technically demanding. The learning curve for MED, UBE, and UE techniques has been estimated to be 30, 58, and 100 cases, respectively, for surgeons with no endoscopic spine surgery experience.41–43 However, for a surgeon familiar with MED or UE techniques, the learning curve for the UBE technique may be significantly less steep. After overcoming the learning curve, the UBE technique can be a very powerful surgical technique to treat various degenerative spine disorders in the lumbar, thoracic, and cervical spines.
In conclusion, the UBE technique is safe and effective with promising and encouraging treatment outcomes for DLCS in relieving pain and neurological symptoms. However, the follow-up period in most of the studies included in this review is relatively short. Therefore, to effectively assess the theoretical advantages of the UBE technique on segmental instability and paraspinal muscles, a long-term comparative study is required.
Footnotes
Funding The author(s) received no financial support for the research, authorship, and/or publication of this article.
Declaration of Conflicting Interests The authors report no conflicts of interest in this work.
- This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2021 ISASS. To see more or order reprints or permissions, see http://ijssurgery.com.
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