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Demographics Patient-Reported Penicillin Allergy (n = 7497) No Penicillin Allergy (n = 278,545) P Value Age, y 0.410 <65 1662 (22.2%) 63,023 (22.6%) 65–69 2025 (27.0%) 76,403 (27.4%) 70–74 1751 (23.4%) 63,639 (22.8%) 75–79 1233 (16.4%) 44,822 (16.1%) 80–84 598 (8.0%) 21,402 (7.7%) ≥85 164 (2.2%) 6355 (2.3%) Gender <0.001 Male 2041 (27.2%) 105,212 (37.8%) Female 5392 (71.9%) 170,432 (61.2%) Unknown 64 (0.9%) 2901 (1.0%) Region <0.001 Midwest 1463 (19.5%) 72,523 (26.0%) Northeast 792 (10.6%) 36,314 (13.0%) South 3673 (49.0%) 122,287 (43.9%) West 1567 (20.9%) 47,406 (17.0%) Unknown 2 (<0.1%) 15 (<0.1%) Elixhauser Comorbidity Index, mean ± SD 4.9 ± 2.0 4.7 ± 2.0 <0.001 Note: Data presented as n (%) unless otherwise noted.
Factor PA, n (%) No PA, n (%) OR (95% CI) P Value Surgical site infections 288 (3.8%) 8695 (3.1%) 1.20 (1.07–1.36) 0.002 Urinary tract infections 924 (12.3%) 27,968 (10.0%) 1.16 (1.08–1.24) <0.001 Sepsis 109 (1.5%) 3253 (1.2%) 1.24 (1.02–1.50) 0.026 Acute kidney injury 283 (3.8%) 8931 (3.2%) 1.19 (1.05–1.34) 0.006 Pneumonia 185 (2.5%) 6919 (2.5%) 0.99 (0.85–1.14) 0.853 All-cause readmissions 735 (9.8%) 23,696 (8.5%) 1.15 (1.07–1.25) <0.001 Abbreviations: PA, penicillin allergy.
Note: Boldface indicates statistically significant findings.
Factor PA, Mean ± SD No PA, Mean ± SD Risk-Adjusted Marginal Cost (Ref: No PA) P Value Inpatient charges $87,565 ± $53,290 $81,385 ± $51,222 +$4340 (SE: 583) <0.001 Inpatient reimbursements $22,891 ± $8931 $21,587 ± $8827 $1221 (SE: 100) <0.001 Abbreviations: PA, penicillin allergy; SE, standard error.
Note: Boldface indicates statistically significant findings.
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