Preoperative Predictors of Survival in Patients With Spinal Metastatic Disease

Article Figures & Data

Table 1

Surgical complications and patient mortality (N = 104).

Complications	n (%)
Surgical complications
Return to the operating room (within 30 d)	8 (7.7%)
Infection	2 (1.9%)
Hematoma	3 (2.9%)
Wound dehiscence (within 30 d)	2 (1.9%)
Deaths	55 (52.9%)
Postoperative survival, d, median (IQR)	103 (41.5–264.5)
Cases that underwent local preoperative radiation	33 (31.7%)

Table 2

Preoperative performance status and health markers.

Karnofsky Performance Status Score (%)	n (%)	Eastern Cooperative Oncology Group Grade	n (%)	American Society of Anesthesiologists Score	n (%)
30	3 (3.3%)	0	12 (17.4%)	1	0
40	10 (11.1%)	1	36 (52.2%)	2	13 (17.3%)
50	11 (12.2%)	2	14 (20.3%)	3	59 (78.7%)
60	8 (8.9%)	3	4 (5.8%)	4	3 (4%)
70	23 (25.6%)	4	3 (4.3%)
80	19 (21.1%)
90	15 (16.7%)
100	1 (1.1%)
Total	90		69		75

Table 3

Preoperative predictors of time to death in patients with spinal metastatic disease.

Radiation Status	No PR	PR
Number of cases (% of total)	71 (68.3%)	33 (31.7%)
Age, y, mean (range)	59.9 (87.3–35.8)	63 (31.6–85.7)
Body mass index, mean (range)	27.6 (16.8–42.9)	26.2 (16–37.8)
Surgical complications (infection, wound hematoma, and dehiscence), n (%)	8 (11.3%)	0
Deaths, n (%)	31 (44%)	24 (73%)
Time to death, d, mean (range)	178.5 (2–897)	218.5 (3–889)
Hazard ratio		1.84
P value		0.034

Note: We performed multivariate survival analysis using Cox proportional hazards model while accounting for the following variables, which demonstrated significance on univariate analysis (P < 0.05): SINS score, local radiation before surgery, presence of liver metastasis, primary melanoma, and primary genitourinary cancer.
PR, preoperative radiation; SINS, spine instability neoplastic score.